tag:blogger.com,1999:blog-88093220539855875592024-03-05T16:13:10.828-08:00williamrussswilliamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.comBlogger1202125tag:blogger.com,1999:blog-8809322053985587559.post-32444924936797966732013-11-07T18:53:00.001-08:002013-11-07T18:53:58.491-08:00Apple updates iBooks for Mavericks with bug fixes<div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p><img src="http://www.imore.com/sites/imore.com/files/styles/large/public/field/image/2013/10/mavericks_ibooks_hero.jpg?itok=wUru63Me" width="1240" height="930" alt="Apple updates iBooks for Mavericks with bug fixes" class="image-large aligncenter" /></p> <p>Apple has posted iBooks Update 1.0.1 for Mac users who are using OS X 10.9 Mavericks. The update is available through Software Update.</p> <p>The update sports typically terse Apple release notes:</p> <blockquote> <p>This version of iBooks includes bug fixes and improvements to performance and stability.</p> </blockquote> </div></div></div><div id="comment-wrapper-nid-21445"></div><img width='1' height='1' src='http://tipb.com.feedsportal.com/c/33998/f/616881/s/336e0c84/sc/28/mf.gif' border='0'/><br clear='all'/><div class='mf-viral'><table border='0'><tr><td valign='middle'><a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fwww.imore.com%2Fapple-updates-ibooks-mavericks-bug-fixes&t=Apple+updates+iBooks+for+Mavericks+with+bug+fixes" target="_blank"><img src="http://res3.feedsportal.com/social/twitter.png" border="0" /></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fwww.imore.com%2Fapple-updates-ibooks-mavericks-bug-fixes&t=Apple+updates+iBooks+for+Mavericks+with+bug+fixes" target="_blank"><img src="http://res3.feedsportal.com/social/facebook.png" border="0" /></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fwww.imore.com%2Fapple-updates-ibooks-mavericks-bug-fixes&t=Apple+updates+iBooks+for+Mavericks+with+bug+fixes" target="_blank"><img src="http://res3.feedsportal.com/social/linkedin.png" border="0" /></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fwww.imore.com%2Fapple-updates-ibooks-mavericks-bug-fixes&t=Apple+updates+iBooks+for+Mavericks+with+bug+fixes" target="_blank"><img src="http://res3.feedsportal.com/social/googleplus.png" border="0" /></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fwww.imore.com%2Fapple-updates-ibooks-mavericks-bug-fixes&t=Apple+updates+iBooks+for+Mavericks+with+bug+fixes" target="_blank"><img src="http://res3.feedsportal.com/social/email.png" border="0" /></a></td><td valign='middle'></td></tr></table></div><br/><br/><a href="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/1/rc.htm"><img src="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/1/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/2/rc.htm"><img src="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/2/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/3/rc.htm"><img src="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/sc/28/rc/3/rc.img" border="0"/></a><br/><br/><a href="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/a2.htm"><img src="http://da.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/a2.img" border="0"/></a><img width="1" height="1" src="http://pi.feedsportal.com/r/180263778032/u/49/f/616881/c/33998/s/336e0c84/a2t.img" border="0"/><img src="http://feeds.feedburner.com/~r/TheIphoneBlog/~4/aP7wdzrX-lo" height="1" width="1"/>Source: <a href="http://feedproxy.google.com/~r/TheIphoneBlog/~3/aP7wdzrX-lo/story01.htm">http://feedproxy.google.com/~r/TheIphoneBlog/~3/aP7wdzrX-lo/story01.htm</a><br />Similar Articles: <a href="https://kippt.com/pot99magic/list/clips/17736238">sunday night football</a> <a href="http://www.43things.com/entries/view/6082734">Dustin Keller</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-22616459916808901152013-11-07T18:49:00.001-08:002013-11-07T18:49:37.497-08:00Here, Drink A Nice Glass of Sparkling Clean Wastewater<div id="storytext" readability="199.477302944"><br /><div id="res243763569" class="bucketwrap image large" previewtitle="One man's sewage is another man's drinking water. This pipe, filled with straw-like filters, gets rid of the contaminants in __." readability="9.54397394137"><br /><br /><div class="captionwrap caption" readability="10"><br /><p>One man's sewage is another man's drinking water. This pipe, filled with straw-like filters, gets rid of the contaminants in __.</p><br /></div><br /><span class="creditwrap"><span class="credit">Amy Standen</span>/<span class="rightsnotice">KQED</span></span><br /><br /><div class="enlarge_html image_data" readability="10"><br /><p class="caption">One man's sewage is another man's drinking water. This pipe, filled with straw-like filters, gets rid of the contaminants in __.</p><br /><span class="creditwrap"><span class="credit">Amy Standen</span>/<span class="rightsnotice">KQED</span></span></div><br /></div><br /><p>In California's Silicon Valley, there will soon be a new source of water for residents. That may not sound like big news, but the source of this water – while certainly high-tech — is raising some eyebrows.</p><br /><p>With freshwater becoming more scarce in many parts of the country, the public may have to overcome its aversion to water recycling.</p><br /><p><strong>Ah, The Stench Of Drinking Water</strong></p><br /><p>If text could transmit odor, you'd already know where this water is coming from.</p><br /><p>"Well, we happen to be very close to a landfill," says Marty Grimes, a spokesman for the brand-new $68 million Silicon Valley Advanced Water Purification Center in San Jose.</p><br /><p>There's also a wastewater treatment plant across the street. And that is where this water comes from: a place that smells a lot like a toilet.</p><br /><div id="res243763775" class="bucketwrap image medium" previewtitle="This hydrant carries __ water to/from the treatment plant." readability="6.41317365269"><br /><br /><div class="captionwrap caption" readability="7"><br /><p>This hydrant carries __ water to/from the treatment plant.</p><br /></div><br /><span class="creditwrap"><span class="credit">Amy Standen</span>/<span class="rightsnotice">KQED</span></span><br /><br /><div class="enlarge_html image_data" readability="7"><br /><p class="caption">This hydrant carries __ water to/from the treatment plant.</p><br /><span class="creditwrap"><span class="credit">Amy Standen</span>/<span class="rightsnotice">KQED</span></span></div><br /></div><br /><p>"Wastewater is not necessarily a pretty business," says Grimes. "But let me tell you, the result of our plant is going to be pure, clean water."</p><br /><p>It's a little unfair to linger on the unsavory sewage source. When this plant starts up later this year, it will be doing some of the most <a href="http://www.valleywater.org/SVAWPC.aspx">state-of-the-art</a> water filtration in the country.</p><br /><p>Naturally, that's what engineers here emphasize when they give tours.</p><br /><p>"The water comes from the autostrainers, where it's strained down to 300 microns," says Crystal Yezman, who works at the facility. One micron is one thousandth of a millimeter, so 300 microns is about the size of a human hair.</p><br /><p>That's step one — filtering out everything wider than a human hair.</p><br /><p>Then, the water passes through filters that get rid of the <a href="http://www.npr.org/templates/story/story.php?storyId=88062858">tiniest of contaminants</a>, like viruses or pharmaceuticals, by a process of <a href="http://www.wqa.org/sitelogic.cfm?ID=872">reverse osmosis</a>.</p><br /><p>Finally, the water gets zapped by ultraviolet rays, which scramble the DNA of anything that might be living in it. This water is clean.</p><br /><p>"The Department of Health has acknowledged that we are removing 99.99 percent of all pathogens," says Yezman.</p><br /><p>If that's true, then the water is cleaner than <a href="http://www.backpacker.com/water-purification-snow-hiking/community/ask_buck/412">snow melt</a>, and certainly almost as good as what people get from their kitchen sinks now.</p><br /><p>Or, says Grimes, "it could be even better."</p><br /><p><strong>Erasing A Dirty Past</strong></p><br /><p>Despite how clean this water is, no one's going to drink it. It's going into segregated pipes bound for landscaping instead.</p><br /><p>But that may have to change one day because, like <a href="http://stateimpact.npr.org/texas/2012/04/24/op-doc-taking-the-waste-out-of-wastewater/">a lot of places</a> in the West, water supplies here are drying up. Recycled water is the future — if enough people can be convinced that it's OK to drink.</p><br /><p>"You have to break the memory, or the line of history, of the water," explains Brent Haddad of the University of California, Santa Cruz.</p><br /><p>This is not an engineering challenge, he says. It's a <a href="http://www.npr.org/2011/08/16/139642271/why-cleaned-wastewater-stays-dirty-in-our-minds">psychological challenge</a>. Water managers, he says, need to rewrite the history of the water to help people forget the part about sewage.</p><br /><p>One way to do this is to take recycled water and put it back into a natural setting, like a river.</p><br /><p>A "river is something that's comforting to people," says Haddad. "And we don't have to think anymore that it was passing through a city. We just begin the history of that water in the river itself."</p><br /><br /><p><strong>Nine Years Of Convincing</strong></p><br /><p>This, of course, happens in nature every day. Just look at the Mississippi River — it's full of treated sewage water that people downstream clean and then drink.</p><br /><p>And it's happening in Southern California, home to the largest <a href="http://www.watereuse.org/association">potable water</a> recycling facility in the world.</p><br /><p>"We put it back into the ground, and then eventually it becomes part of the water supply," says Mike Markus, general manager of the facility.</p><br /><p>Instead of putting their water into a river, his district cleans treated sewage and then pumps it underground, where it mixes with other water. Then, they pump it back up and treat it all over again, before piping it to peoples' houses.</p><br /><p>Even with this crazy, Rube Goldbergian system, getting the public to accept recycled water took lots of meetings.</p><br /><p>Markus says he and his colleagues talked to almost anyone who would listen — local elected officials, the health and medical community, the chamber of commerce, schools, environmentalists, rotary groups.</p><br /><p>"We talked to the Sons and Daughters of the American Revolution. And scouting troops," Markus adds. "Anyone who would want to hear or receive a presentation."</p><br /><p>That whole process took nine years.</p><br /><p>The irony, of course, is that when you put recycled water back into the ecosystem, it actually gets dirtier and has to be treated again. How does it feel to put that beautiful clean water into a hole in the ground? "Frustrated," Markus says.</p><br /><p>So, he reminds himself that winning people over to recycled sewage water is a process — one that's just beginning here in Silicon Valley.</p><br /></div>Source: <a href="http://www.npr.org/2013/11/07/243711364/here-drink-a-nice-glass-of-sparkling-clean-wastewater?ft=1&f=1001">http://www.npr.org/2013/11/07/243711364/here-drink-a-nice-glass-of-sparkling-clean-wastewater?ft=1&f=1001</a><br />Tags: <a href="http://eportfolio.hcu.edu.tw/blog/files/6-13495-22453.php">Jaimie Alexander</a> <a href="http://eportfolio.ncku.edu.tw/article.php?u=K46981065&i=20110327">last minute halloween costumes</a> <a href="http://export.gov/wcm/fragments/fl_eg_outsidelinks/redirect.asp?URL=http://how_to_get_instagram_followers_fast_for_free.dikililisesi.net/">Geno Smith</a> <a href="http://faithformation.ctratco.com/connect/list-of-blogs/entry/third-sunday-of-advent">Hyon Song-wol</a> <a href="http://fortuity.zuffolin.www.0l.ro/basisdaten/verhaltest/nachtwin/detachedness">neil armstrong</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-15798658241985014702013-11-07T18:45:00.001-08:002013-11-07T18:45:02.045-08:00Penny Marshall, Cindy Williams together again<figure class=" cover get-lbdata-from-dom go-to-slideshow-lightbox " data-id="8c3b6700-36a3-33de-a4de-0f612978905a"><br /> <br /> <br /> </figure><p>This image released by Nickelodeon shows, from left, Penny Marshall, Jennette McCurdy, Ariana Grande and Cindy Williams in a scene from the series "Sam & Cat." Marshall and Williams, best known from their comedy series "Laverne and Shirley," will guest star in the episode airing Saturday, Nov. 9, at 8 p.m. EST. (AP Photo/Nickelodeon, Lisa Rose)</p><br /> <br /> <br /> <br /> <!-- google_ad_section_start --><br /> <meta itemprop="datePublished" content="2013-11-07T18:38:45Z"/><meta itemprop="headline" content="Penny Marshall, Cindy Williams together again"/><meta itemprop="alternativeHeadline" content=""/><meta itemprop="image" content="http://media.zenfs.com/en_us/News/ap_webfeeds/bf1441038d847225420f6a7067007f68.jpg"/><meta itemprop="description" content="LOS ANGELES (AP) — Penny Marshall and Cindy Williams play feuding ex-TV partners on an episode of Nickelodeon's "Sam & Cat," but they brush aside any comparison to their past."/><p>LOS ANGELES (AP) — Penny Marshall and Cindy Williams play feuding ex-TV partners on an episode of Nickelodeon's "Sam & Cat," but they brush aside any comparison to their past.</p><p>The former "Laverne & Shirley" stars, who back in the day of their 1976-83 sitcom were reported to have crossed swords, said they were never enemies and remain friends despite lingering suggestions to the contrary.</p><p>"That was rumors. Any show you work on for eight years, you're gonna argue at some point," said Marshall. "Way overblown."</p><p>Williams agreed, but added a bit of detail.</p><p>"Yes, it was a bit overblown," she said. The actress added that she and Marshall have "very different personalities" with contradictory styles of working, which sometimes led to on-set clashes.</p><p>That said, Williams regularly visits Marshall's house to watch and discuss TV. There's a chill in the air, Williams said, but only because Marshall keeps her thermostat turned down and, to compensate, provides down coats and blankets for guests.</p><p>Marshall, whose big-screen directing credits include "A League of Their Own" and "Big," is busy working on a documentary about provocative ex-NBA player Dennis Rodman. But she and Williams were enticed by "Sam & Cat" creator Dan Schneider to guest star on the comedy airing at 8 p.m. EST on Saturday.</p><p>"He loved our show," Williams said. "He wanted to do a little tribute."</p><p>In the episode, Sam (Jennette McCurdy) and Cat (Ariana Grande) face having to rename their baby-sitting business because it's similar to "Salmon Cat," a faux 1970s TV show. The young women track down the show's creators (Marshall and Williams) and try to dissolve their enmity.</p><p>In another Nickelodeon reunion, "Happy Days" creator Garry Marshall (brother of Penny Marshall), makes a guest appearance on "See Dad Run" starring Scott Baio, a cast member on the 1974-84 sitcom starring Henry Winkler and Ron Howard.</p><p>The "See Dad Run" episode airs 8 p.m. EST on Sunday.</p><p>___</p><p>Online:</p><p>http://www.nick.com</p><ul id="topics" class="hidden"><li data-id="YCT:001000031">Arts & Entertainment</li><li data-id="YCT:001000069">Celebrities</li><li data-id="WIKIID:Cindy_Williams">Cindy Williams</li><li data-id="WIKIID:Penny_Marshall">Penny Marshall</li><li data-id="WIKIID:Garry_Marshall">Garry Marshall</li></ul><!-- google_ad_section_end -->Source: <a href="http://news.yahoo.com/penny-marshall-cindy-williams-together-again-152213089.html">http://news.yahoo.com/penny-marshall-cindy-williams-together-again-152213089.html</a><br />Category: <a href="http://bookmarkitnow.com/story.php?title=in-vitro-fertilization-3">Monster Mash</a> <a href="http://realnewscenter.com/story.php?title=in-vitro-fertilization-steps-2">eric decker</a> <a href="http://aboutbookmark.com/story.php?title=in-vitro-fertilization-steps-2">House of Cards</a> <a href="http://voguishcreations.net/story.php?title=in-vitro-fertilization-2">Brad Culpepper</a> <a href="http://bookmarkitnow.com/story.php?title=embryo-transfert">Mayweather vs Canelo results</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-76932626938073059072013-11-07T18:40:00.001-08:002013-11-07T18:40:35.415-08:00Apple posts two EFI updates for late 2013 MacBook Pros with Retina Displays<div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p><img src="http://www.imore.com/sites/imore.com/files/styles/large/public/field/image/2013/05/macbook_pro_retina_angle_0.jpg?itok=LPY4ahs6" width="1240" height="930" alt="Apple posts two EFI updates for late 2013 MacBook Pros with Retina Displays" class="image-large aligncenter" /></p> <p>Apple on Thursday posted two firmware updates for the late 2013 MacBook Pro with Retina Display - <a href="http://support.apple.com/kb/DL1705">MacBook Pro Retina EFI Update v1.2</a> and <a href="http://support.apple.com/kb/DL1704">MacBook Pro Retina EFI Update v1.3</a>.</p> <p>The 1.2 update is specifically aimed at models equipped with Nvidia graphics, and updates a problem that, "in rare cases, may limit the performance of the discrete graphics processor after a system wake or boot."</p> <p>The 1.3 update is recommended specifically for 13-inch models, and fixes an issue that cause the built-in keyboard and Multi-Touch trackpad to become unresponsive.</p> </div></div></div><div id="comment-wrapper-nid-21444"></div><img width='1' height='1' src='http://tipb.com.feedsportal.com/c/33998/f/616881/s/336df8b4/sc/28/mf.gif' border='0'/><br clear='all'/><div class='mf-viral'><table border='0'><tr><td valign='middle'><a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fwww.imore.com%2Fapple-posts-two-efi-updates-late-2013-macbook-pros-retina-displays&t=Apple+posts+two+EFI+updates+for+late+2013+MacBook+Pros+with+Retina+Displays" target="_blank"><img src="http://res3.feedsportal.com/social/twitter.png" border="0" /></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fwww.imore.com%2Fapple-posts-two-efi-updates-late-2013-macbook-pros-retina-displays&t=Apple+posts+two+EFI+updates+for+late+2013+MacBook+Pros+with+Retina+Displays" target="_blank"><img src="http://res3.feedsportal.com/social/facebook.png" border="0" /></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fwww.imore.com%2Fapple-posts-two-efi-updates-late-2013-macbook-pros-retina-displays&t=Apple+posts+two+EFI+updates+for+late+2013+MacBook+Pros+with+Retina+Displays" target="_blank"><img src="http://res3.feedsportal.com/social/linkedin.png" border="0" /></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fwww.imore.com%2Fapple-posts-two-efi-updates-late-2013-macbook-pros-retina-displays&t=Apple+posts+two+EFI+updates+for+late+2013+MacBook+Pros+with+Retina+Displays" target="_blank"><img src="http://res3.feedsportal.com/social/googleplus.png" border="0" /></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fwww.imore.com%2Fapple-posts-two-efi-updates-late-2013-macbook-pros-retina-displays&t=Apple+posts+two+EFI+updates+for+late+2013+MacBook+Pros+with+Retina+Displays" target="_blank"><img src="http://res3.feedsportal.com/social/email.png" border="0" /></a></td><td valign='middle'></td></tr></table></div><br/><br/><a href="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/1/rc.htm"><img src="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/1/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/2/rc.htm"><img src="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/2/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/3/rc.htm"><img src="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/sc/28/rc/3/rc.img" border="0"/></a><br/><br/><a href="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/a2.htm"><img src="http://da.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/a2.img" border="0"/></a><img width="1" height="1" src="http://pi.feedsportal.com/r/180263732572/u/49/f/616881/c/33998/s/336df8b4/a2t.img" border="0"/><img src="http://feeds.feedburner.com/~r/TheIphoneBlog/~4/rCY9I4GiLO0" height="1" width="1"/>Source: <a href="http://feedproxy.google.com/~r/TheIphoneBlog/~3/rCY9I4GiLO0/story01.htm">http://feedproxy.google.com/~r/TheIphoneBlog/~3/rCY9I4GiLO0/story01.htm</a><br />Similar Articles: <a href="http://blogs.crikey.com.au/pollbludger/2012/02/25/nielsen-53-47-to-coalition-among-other-things/all-comments/">Daylight Savings Time 2013</a> <a href="http://blogs.crikey.com.au/pollbludger/2012/02/27/gillard-73-rudd-29/comment-page-62/">Google Glass</a> <a href="http://blogs.crikey.com.au/pollbludger/2013/01/12/seat-of-the-week-solomon/">Mary Queen of Scots</a> <a href="http://blogs.crikey.com.au/pollbludger/2012/03/01/morgan-face-to-face-52-48-to-coalition-2/">Shannon Sharpe</a> <a href="http://wiki.goodtogreatfoss.org/index.php?title=Understanding_Australian_Politics">aaron hernandez</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-61378886201843014032013-11-07T18:35:00.001-08:002013-11-07T18:35:54.325-08:005 ways BYOD is shaking up tech support<div id="main_text" readability="41.2075471698"><br /><br /><p>November 07, 2013</p><br /><br /><br /><br /><br /><div itemprop="articleBody" readability="27.697228145"><br /><p>Amid the clamor of "bring your own device" (BYOD), a question lurks in the background: "What happens to technical service and support?" Concerns for the tech support function encompass the extremes, from agents being overwhelmed with calls, to their becoming inhabitants of a help desk ghost town.</p><br /><p>On the one hand, it’s easy to imagine a flood of calls as employees attempt to access wireless networks or synch their e-mail, especially in companies that permit the use of any device type. At the same time, as more people own smartphones, they are increasingly accustomed to resolving issues independently, through online forums, communities and other means of self-support.</p><br /><p>By 2016, says Gartner analyst Jarod Greene, help desks will see a 25% to 30% drop in user-initiated call volume, as BYOD drives a companion trend of BYOS, or “bring your own support.”</p><br /><a href="http://reg.idgenterprise.com/insider.html?url=http://www.infoworld.com/d/consumerization-of-it/5-ways-byod-shaking-tech-support-230379?1383860830" id="insider_action"/><br /><h4><a href="http://reg.idgenterprise.com/insider.html?url=http://www.infoworld.com/d/consumerization-of-it/5-ways-byod-shaking-tech-support-230379?1383860830" id="insider_action">To continue reading, register here to become an Insider</a></h4><br /><h5><a href="http://reg.idgenterprise.com/insider.html?url=http://www.infoworld.com/d/consumerization-of-it/5-ways-byod-shaking-tech-support-230379?1383860830" id="insider_action">It's FREE to join</a></h5><br /><br /></div><br /><br /></div>Source: <a href="http://www.infoworld.com/d/consumerization-of-it/5-ways-byod-shaking-tech-support-230379?source=rss_mobile_technology">http://www.infoworld.com/d/consumerization-of-it/5-ways-byod-shaking-tech-support-230379?source=rss_mobile_technology</a><br />Related Topics: <a href="http://www.haberkartallari.com/resmin-uzerine-tiklayarak-diger-resme-gecebilirsiniz/resmin-uzerine-tiklayarak-diger-resme-gecebilirsiniz-22">chris christie</a> <a href="http://thefightingnews.com/cfa-11-hd-shots-from-the-fighting-news/img_1105/">samhain</a> <a href="http://kalima.tn/web/%D8%AD%D8%A7%D8%AF%D8%AB-%D9%85%D8%B1%D9%88%D8%B1-%D8%AC%D8%B1%D8%A8%D8%A9-%D8%AC%D8%B1%D8%AC%D9%8A%D8%B3/">harry potter</a> <a href="http://www.feniks-shapki.ru/?page_id=59">gucci mane</a> <a href="http://amnas-001.supercloud.hk/wpblog/?p=1030">Cal Worthington</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-42275274746402743302013-11-07T18:31:00.001-08:002013-11-07T18:31:41.303-08:00Twitter shares rocket 92% higher in NYSE debut<!-- google_ad_section_start --><br /><br /> <p class="first">By Olivia Oran and Gerry Shih</p><br /> <p>Nov 7 (Reuters) - Twitter Inc stock soared 92<br />percent in their first day of trading on Thursday on the New<br />York Stock Exchange as investors snapped up shares in the<br />microblogging site, pushing its market value to a heady $25<br />billion.</p><br /> <p>The shares opened at $45.10 a share, up from the initial<br />public offering price of $26 set on Wednesday, then added to<br />those gains, hitting a high of $50.</p><br /> <p>Sources said the flotation had drawn strong demand, with<br />investors asking for 30 times the number of shares on offer as<br />they bet on potential growth at the money-losing social media<br />company.</p><br /> <p>The opening price valued the shares at about 22 times<br />forecast 2014 sales, nearly double that multiple at social media<br />rivals Facebook Inc and LinkedIn Corp.</p><br /> <p>Twitter executives including Chief Executive Dick Costolo<br />and founder Jack Dorsey thronged to the floor of the New York<br />Stock Exchange to witness the IPO. The Big Board snatched the<br />offering away from Nasdaq after the normally tech-focused Nasdaq<br />stumbled with the larger Facebook flotation last year.</p><br /> <p>"Facebook was so overhyped people felt like they couldn't<br />miss out," said Kenneth Polcari, a senior floor official at<br />O'Neil Securities Inc. "Twitter isn't like that, though you can<br />feel the excitement."</p><br /> <p>British actor Patrick Stewart rang the opening bell at the<br />exchange together with 9-year-old Vivienne Harr, who started a<br />charity to end childhood slavery using the microblogging site.</p><br /> <p>"I guess I represent the poster boy for Twitter," Stewart<br />said, adding that he had only been tweeting for about a year and<br />wasn't buying Twitter stock today.</p><br /> <p>Twitter's building staff opened its offices in San Francisco<br />extra early, at 5:30 a.m. on Thursday. By 7:30 a.m., hundreds of<br />employees had flocked to their 9th floor cafeteria to watch<br />Stewart ring the opening bell on TV.</p><br /> <p>The microblogging network priced its 70 million shares at<br />above the targeted range of $23 to $25, which had been raised<br />once before. The IPO values Twitter at $14.1 billion, with the<br />potential to reach $14.4 billion if underwriters exercise an<br />overallotment option.</p><br /> <p>If the full overallotment is exercised, as expected, Twitter<br />could raise $2.1 billion, making it the second largest Internet<br />offering in the United States behind Facebook Inc's $16<br />billion IPO last year and ahead of Google Inc's 2004<br />IPO, according to Thomson Reuters data.</p><br /> <p>Twitter boasts 230 million global users, including heads of<br />state and celebrities, but it lost $65 million in its most<br />recent quarter and questions remained about long-term prospects.</p><br /> <p>It also lacks the ubiquity of Facebook or the "stickiness"<br />factor that keeps people checking the No. 1 social network on a<br />daily basis.</p><br /> <p>A Reuters-Ipsos poll last month showed that 36 percent of<br />people who signed up for a Twitter account say they do not use<br />it.</p><br /><br /><!-- google_ad_section_end -->Source: <a href="http://finance.yahoo.com/news/twitter-set-debut-ipo-30-141551118.html">http://finance.yahoo.com/news/twitter-set-debut-ipo-30-141551118.html</a><br />Category: <a href="http://www.shoplocally.com/1law">Bad Grandpa</a> <a href="http://411.ca/business/profile/1172360">cnn</a> <a href="http://oakville-on.opendi.ca/832208.html">breaking bad</a> <a href="http://www.dakitaki.com/business-directory/Dundas-Chiropractic-Centre">monday night football</a> <a href="http://www.esourcecanada.com/profile.asp?company_id=113915733">nfl scores</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-28221985368148096312013-11-07T18:26:00.001-08:002013-11-07T18:26:52.646-08:00The Carolina hammerhead, a new species of shark, debuts<head><title>The Carolina hammerhead, a new species of shark, debuts</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="University of South Carolina biologist Joe Quattro led a team that recently described a new species of hammerhead shark. His discovery is the result of years of study of the rivers and coastal waters of South Carolina."/><meta name="keywords" content="Biology Evolution Genetics Marine/Freshwater Biology"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Zootaxa"/><meta name="type" content="research"/><meta name="institution" content="University of South Carolina"/><meta name="meeting" content=""/><meta name="region" content="namerica"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="178.089526293"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Steven Powell<br/>spowell2@mailbox.sc.edu<br/>803-777-1923<br/><span class="relinst">University of South Carolina</span><br /><br /><br/></p><br /><h2 class="subtitle"/><br /><br /> <!-- Begin image here --><br /><!-- End image here --><p>Discovering a new species is, among biologists, akin to hitting a grand slam, and University of South Carolina ichthyologist Joe Quattro led a team that recently cleared the bases. In the journal <i>Zootaxa</i>, they describe a rare shark, the Carolina hammerhead, that had long eluded discovery because it is outwardly indistinguishable from the common scalloped hammerhead. Through its rarity, the new species, <i>Sphyrna gilberti</i>, underscores the fragility of shark diversity in the face of relentless human predation.</p> <br /> <p>Quattro, a biology professor in USC's College of Arts and Sciences, didn't set out to discover a new cryptic species, let alone one found exclusively in saltwater. When he started as an assistant professor at USC in 1995, he was largely focused on fish in the freshwater rivers that flow through the state before emptying into the western Atlantic Ocean.</p> <br /> <p>He has wide interests that include conservation, genetic diversity and taxonomy. A driving force in his scientific curiosity is a desire to better understand evolution. As it turns out, South Carolina's four major river basins the Pee Dee, the Santee, the Edisto and the Savannah are a source of particularly rich ore for mining insight into evolutionary history. <br /><b/></p><p>Glacial influence had limits</p> <br /> <p>Quattro grew up in Maryland, earned a doctorate at Rutgers University in New Jersey, and completed a post-doc at Stanford University. "New Jersey and Maryland, in particular, had huge glacial influences," said Quattro. "The areas where rivers now flow were covered with glaciers until 10,000 to 15,000 years ago, and as the glaciers receded the taxa followed them upstream."</p> <br /> <p>In contrast, rivers south of Virginia were not covered with glaciers. "In other words, these rivers have been around for quite some time," Quattro said. "The Pee Dee and the Santee are two of the largest river systems on the East coast. And we just got curious how distinct are these rivers from one another?"</p> <br /> <p>Beginning with the pygmy sunfish, Quattro and colleagues examined the genetic makeup of fish species within the ancient freshwater drainage systems. They found the banded pygmy sunfish in all the South Carolina rivers in fact, this widespread species is found in nearly all the river systems of the U.S. southeastern and Gulf coasts, starting from the plains of North Carolina, around Florida, and all the way to and up the Mississippi River.</p> <br /> <p>But two species are much rarer. The bluebarred pygmy sunfish is found only in the Savannah and Edisto systems. The Carolina pygmy sunfish is found only in the Santee and Pee Dee systems. Both species coexist with the common banded pygmy sunfish in these river systems, but are found nowhere else in the world.</p> <br /> <p>From an evolutionary standpoint, it's a noteworthy finding. These rare species are related to the widespread species, yet the details of the inter-relationships such as which predates the others and is thus an ancestral species still defy ready description. The fact that a rare and a common species are located together in an ancient river system is important information in the ongoing struggle to clearly define evolutionary history. In the past, scientists drew taxonomic charts almost solely on the basis of physical structure (morphology) and available fossils. The genetic data revolution of recent decades is helping redefine biology in a much more precise manner, but the process is still in the early going. <br /><b/></p><p>From the river to the sea</p> <br /> <p>Quattro has been doing his part by slowly moving down the river systems to the ocean, collecting genetic data the whole way down. In the freshwater rivers, he has examined pygmy sunfishes, other sunfishes and basses. Closer to the sea, he has looked at short-nosed sturgeon, which spend most of their time in the estuary (where the river meets the ocean), but do venture up the river to spawn. And further downriver still, he has looked at shark pups.</p> <br /> <p>South Carolina is a well-known pupping ground for several species of sharks, including the hammerhead. The female hammerhead will birth her young at the ocean-side fringes of the estuary; the pups remain there for a year or so, growing, before moving out to the ocean to complete their life cycle.</p> <br /> <p>In the process of looking at hammerheads, Quattro, his student William Driggers III and their colleagues quickly uncovered an anomaly. The scalloped hammerheads (<i>Sphyrna lewini</i>) that they were collecting had two different genetic signatures, in both the mitochondrial and nuclear genomes. Searching the literature, they found that Carter Gilbert, the renowned curator of the Florida Museum of Natural History from 1961 to 1998, had described an anomalous scalloped hammerhead in 1967 that had 10 fewer vertebrae than <i>S. lewini</i>. It had been caught near Charleston and, because the sample was in the National Museum of Natural History, the team was able to examine it morphologically and suggest that it constituted a cryptic species that is, one that is physically nearly indistinguishable from the more common species.</p> <br /> <p>After publishing the preliminary genetic evidence for the new, cryptic species in the journal <i>Marine Biology</i> in 2006, Quattro and colleagues followed up by making thorough measurements (of 54 cryptic individuals and 24 S. lewini) to fully describe in <i>Zootaxa</i> the new species, <i>S. gilberti</i>, named in Gilbert's honor. The difference in vertebrae, 10 fewer in the cryptic species, is the defining morphological difference.</p> <br /> <p>Apart from the satisfaction of discovery, Quattro has established locations and genetic signatures for a number of closely related, yet distinct, species in South Carolina's rivers, estuaries and coastal waters. The results will go a long way in furthering efforts to accurately define taxonomy and evolutionary history for aquatic life.</p> <br /> <p>His team's work also demonstrates the rarity of the new species. "Outside of South Carolina, we've only seen five tissue samples of the cryptic species," Quattro said. "And that's out of three or four hundred specimens."</p> <br /> <p>Shark populations have greatly diminished over the past few decades. "The biomass of scalloped hammerheads off the coast of the eastern U.S. is less than 10 percent of what it was historically," Quattro said. "Here, we're showing that the scalloped hammerheads are actually two things. Since the cryptic species is much rarer than the <i>lewini</i>, God only knows what its population levels have dropped to." <br /></p> <br /> <br /><p>###</p><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body><html readability="76.7558557264"><head><title>The Carolina hammerhead, a new species of shark, debuts</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="University of South Carolina biologist Joe Quattro led a team that recently described a new species of hammerhead shark. His discovery is the result of years of study of the rivers and coastal waters of South Carolina."/><meta name="keywords" content="Biology Evolution Genetics Marine/Freshwater Biology"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Zootaxa"/><meta name="type" content="research"/><meta name="institution" content="University of South Carolina"/><meta name="meeting" content=""/><meta name="region" content="namerica"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="178.089526293"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Steven Powell<br/>spowell2@mailbox.sc.edu<br/>803-777-1923<br/><span class="relinst">University of South Carolina</span><br /><br /><br/></p><br /><h2 class="subtitle"/><br /><br /> <!-- Begin image here --><br /><!-- End image here --><p>Discovering a new species is, among biologists, akin to hitting a grand slam, and University of South Carolina ichthyologist Joe Quattro led a team that recently cleared the bases. In the journal <i>Zootaxa</i>, they describe a rare shark, the Carolina hammerhead, that had long eluded discovery because it is outwardly indistinguishable from the common scalloped hammerhead. Through its rarity, the new species, <i>Sphyrna gilberti</i>, underscores the fragility of shark diversity in the face of relentless human predation.</p> <br /> <p>Quattro, a biology professor in USC's College of Arts and Sciences, didn't set out to discover a new cryptic species, let alone one found exclusively in saltwater. When he started as an assistant professor at USC in 1995, he was largely focused on fish in the freshwater rivers that flow through the state before emptying into the western Atlantic Ocean.</p> <br /> <p>He has wide interests that include conservation, genetic diversity and taxonomy. A driving force in his scientific curiosity is a desire to better understand evolution. As it turns out, South Carolina's four major river basins the Pee Dee, the Santee, the Edisto and the Savannah are a source of particularly rich ore for mining insight into evolutionary history. <br /><b/></p><p>Glacial influence had limits</p> <br /> <p>Quattro grew up in Maryland, earned a doctorate at Rutgers University in New Jersey, and completed a post-doc at Stanford University. "New Jersey and Maryland, in particular, had huge glacial influences," said Quattro. "The areas where rivers now flow were covered with glaciers until 10,000 to 15,000 years ago, and as the glaciers receded the taxa followed them upstream."</p> <br /> <p>In contrast, rivers south of Virginia were not covered with glaciers. "In other words, these rivers have been around for quite some time," Quattro said. "The Pee Dee and the Santee are two of the largest river systems on the East coast. And we just got curious how distinct are these rivers from one another?"</p> <br /> <p>Beginning with the pygmy sunfish, Quattro and colleagues examined the genetic makeup of fish species within the ancient freshwater drainage systems. They found the banded pygmy sunfish in all the South Carolina rivers in fact, this widespread species is found in nearly all the river systems of the U.S. southeastern and Gulf coasts, starting from the plains of North Carolina, around Florida, and all the way to and up the Mississippi River.</p> <br /> <p>But two species are much rarer. The bluebarred pygmy sunfish is found only in the Savannah and Edisto systems. The Carolina pygmy sunfish is found only in the Santee and Pee Dee systems. Both species coexist with the common banded pygmy sunfish in these river systems, but are found nowhere else in the world.</p> <br /> <p>From an evolutionary standpoint, it's a noteworthy finding. These rare species are related to the widespread species, yet the details of the inter-relationships such as which predates the others and is thus an ancestral species still defy ready description. The fact that a rare and a common species are located together in an ancient river system is important information in the ongoing struggle to clearly define evolutionary history. In the past, scientists drew taxonomic charts almost solely on the basis of physical structure (morphology) and available fossils. The genetic data revolution of recent decades is helping redefine biology in a much more precise manner, but the process is still in the early going. <br /><b/></p><p>From the river to the sea</p> <br /> <p>Quattro has been doing his part by slowly moving down the river systems to the ocean, collecting genetic data the whole way down. In the freshwater rivers, he has examined pygmy sunfishes, other sunfishes and basses. Closer to the sea, he has looked at short-nosed sturgeon, which spend most of their time in the estuary (where the river meets the ocean), but do venture up the river to spawn. And further downriver still, he has looked at shark pups.</p> <br /> <p>South Carolina is a well-known pupping ground for several species of sharks, including the hammerhead. The female hammerhead will birth her young at the ocean-side fringes of the estuary; the pups remain there for a year or so, growing, before moving out to the ocean to complete their life cycle.</p> <br /> <p>In the process of looking at hammerheads, Quattro, his student William Driggers III and their colleagues quickly uncovered an anomaly. The scalloped hammerheads (<i>Sphyrna lewini</i>) that they were collecting had two different genetic signatures, in both the mitochondrial and nuclear genomes. Searching the literature, they found that Carter Gilbert, the renowned curator of the Florida Museum of Natural History from 1961 to 1998, had described an anomalous scalloped hammerhead in 1967 that had 10 fewer vertebrae than <i>S. lewini</i>. It had been caught near Charleston and, because the sample was in the National Museum of Natural History, the team was able to examine it morphologically and suggest that it constituted a cryptic species that is, one that is physically nearly indistinguishable from the more common species.</p> <br /> <p>After publishing the preliminary genetic evidence for the new, cryptic species in the journal <i>Marine Biology</i> in 2006, Quattro and colleagues followed up by making thorough measurements (of 54 cryptic individuals and 24 S. lewini) to fully describe in <i>Zootaxa</i> the new species, <i>S. gilberti</i>, named in Gilbert's honor. The difference in vertebrae, 10 fewer in the cryptic species, is the defining morphological difference.</p> <br /> <p>Apart from the satisfaction of discovery, Quattro has established locations and genetic signatures for a number of closely related, yet distinct, species in South Carolina's rivers, estuaries and coastal waters. The results will go a long way in furthering efforts to accurately define taxonomy and evolutionary history for aquatic life.</p> <br /> <p>His team's work also demonstrates the rarity of the new species. "Outside of South Carolina, we've only seen five tissue samples of the cryptic species," Quattro said. "And that's out of three or four hundred specimens."</p> <br /> <p>Shark populations have greatly diminished over the past few decades. "The biomass of scalloped hammerheads off the coast of the eastern U.S. is less than 10 percent of what it was historically," Quattro said. "Here, we're showing that the scalloped hammerheads are actually two things. Since the cryptic species is much rarer than the <i>lewini</i>, God only knows what its population levels have dropped to." <br /></p> <br /> <br /><p>###</p><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body></html>Source: <a href="http://www.eurekalert.org/pub_releases/2013-11/uosc-tch110713.php">http://www.eurekalert.org/pub_releases/2013-11/uosc-tch110713.php</a><br />Related Topics: <a href="http://sundulberita.com/berita/bekannt-im-internet-erfreuliche-urteile-des-bundesgerichtshofs-fuer-anleger-in-sachen-clerical-medical/">courtney stodden</a> <a href="http://extendsocial.com/business/anleger-des-seb-immoinvest-erhalten-die-erste-ausschuettung-aus-liquidation-%7C-pressemitteilungen-kostenlos/">homeland</a> <a href="http://global-trade-news.com/story.php?title=bank-of-england-holds-rates-and-qe-ft-com">Americas Cup</a> <a href="http://mesothelioma-org.com/story.php?title=ubs-3-sector-real-estate-europe-immobilienfonds-erneut-geschlossen-presseecho-de">Wentworth Miller</a> <a href="http://sundulberita.com/berita/anleger-in-sachen-clerical-medical-bekommen-unterstuetzung-vom-bundesgerichtshof-%7C-pressestelle-online/">Rosh Hashanah 2013</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-9121057706176659402013-11-07T18:22:00.001-08:002013-11-07T18:22:51.569-08:001 worm, 2 mouths<head><title>1 worm, 2 mouths</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="Depending on the environment in which the worm grows, the larva of the roundworm Pristionchus pacificus develops into either a wide-mouthed predator or a narrow-mouthed bacteria eater. A team of researchers at the Max Planck Institute for Evolutionary Biology in Tbingen, Germany, headed by Ralf J. Sommer have now discovered a developmental biological switch that determines the worm's mouth form. "/><meta name="keywords" content="Biology Evolution"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Cell"/><meta name="type" content="research"/><meta name="institution" content="Max-Planck-Gesellschaft"/><meta name="meeting" content=""/><meta name="region" content="europe"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="128.504551585"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Erik Ragsdale<br/>erik.ragsdale@tuebingen.mpg.de<br/>49-070-716-01496<br/><span class="relinst">Max-Planck-Gesellschaft</span><br /><br /><br/></p><br /><h2 class="subtitle">A devious evolutionary path between genetics and environment</h2><br /><br /><!-- Begin image here --><br /><!-- End image here --><p>Depending on the environment in which the worm grows, the larva of the roundworm <i><i>Pristionchus</i> pacificus</i> develops into either a wide-mouthed predator or a narrow-mouthed bacteria eater. A team of researchers at the Max Planck Institute for Evolutionary Biology in Tbingen, Germany, headed by Ralf J. Sommer have now discovered a developmental biological switch that determines the worm's mouth form. According to this, the scientists are now able to explain how organisms adapt to different surrounding conditions.</p> <br /> <p>When it comes to survival, flexibility is a trump card. This principle also applies to the microscopic roundworm <i><i>Pristionchus</i> pacificus</i>, which is being researched by scientists at the Max Planck Institute for Developmental Biology in a study headed by Ralf Sommer. Depending on the environment in which <i>Pristionchus</i> grows, it develops either a short wide mouth or a long narrow one. The wide-mouthed variant, which has a single, characteristic tooth, is suitable for carrying out predatory attacks. The narrow version, in contrast, is mainly used for grazing on bacterial food sources. The developmental path taken by a <i>Pristionchus</i> larva is not decided by its genes but by the environment. When the animals were starved or when too many worms crowded the Petri dish, the researchers observed the increased development of the wide-mouthed variant.</p> <br /> <p>Erik Ragsdale, Manuela Mller, Christian Rdelsperger and Ralf Sommer have now discovered a crucial interface between the worm's environment and its developmental genes. The Tbingen-based scientists found a gene which functions like a switch and selects the suitable variant from the two possible mouth forms. </p> <br /> <p>The discovery of this gene was the crowning success of a genetic experiment, to which roundworms are particularly suited due to their short generation time. Ragsdale and Mller discovered mutated worm lines which only produce worms with narrow mouths, irrespective of the environmental conditions, and in which the same gene, eud-1, is inactivated. "We were able to show that a gene that we found in a genetic experiment under laboratory conditions controls an ecologically significant characteristic," comments Max Planck Director Sommer, explaining the special significance of this discovery.</p> <br /> <p>eud-1 is the gene for a sulfatase. Sulfatases are enzymes that chemically alter other proteins or molecules. The scientists in Tbingen do not yet know precisely which molecules are the targets of this special sulfatase. They presume, however, that eud-1 influences the characteristics of hormonal messenger substances. This would fit with their observation that eud-1 is mainly active in the worm's neurons where important messenger substances are produced.</p> <br /> <p>Armed with the information about the eud-1 mutants, Ragsdale and his colleagues crosschecked their findings and introduced additional copies of the eud-1 gene into <i>Pristionchus</i> worms using genetic engineering tricks. Almost all of these transgenic worms developed the wide mouth form with the characteristic tooth.</p> <br /> <p>eud-1 thus works like a train dispatcher at a large railway station who decides which platform a high-speed train can pull into based on the current traffic situation. During a critical phase in the worm's development, it follows the one-way track to a "wide mouth" or "narrow mouth".</p> <br /> <p>The capacity of many organisms to tailor their development to the changing demands of the environment is known as "phenotypic plasticity". The discovery of the des eud-1 gene is important because the molecular-genetic mechanisms that facilitate this plasticity in the animals have been largely unknown up to now. </p> <br /> <p>"Phenotypic plasticity is often referred to as an explanation for evolutionary adaptations to different environmental conditions. We provide an example of a genetic mechanism that enables such evolutionary bifurcations," says Sommer.</p> <br /> <p>Exactly how the environment and genes interact is a controversial topic among evolutionary biologists in certain respects. It is clear that the environment selects between genetically different variants this is Darwin's natural selection. However, researchers like American biologist Mary-Jane West-Eberhard claim that the environment can also directly influence the emergence of new phylogenetic characteristics.</p> <br /> <p>In the case of a "plastic" characteristic like the shape of the mouth aperture, external circumstances determine whether it presents in one form or another. West-Eberhard and other scientists suspect that a characteristic determined by the environment in this way can then become permanently defined at genetic level. Speciation or the division of species could even arise in this manner. However, this is little more than a controversial theory, for which hardly anything by way of experimental proof could be provided to date.</p> <br /> <p>With the discovery of the switch gene eud-1, the Max Planck scientists in Tbingen have identified a genetic mechanism that fits well with this hypothesis. Hence, complex evolutionary models with plasticity and environmental influences as driving forces may perhaps be more than controversial musings.</p> <br /> <p>###</p> <br /> <p><b>Original publication</b> <br /></p><p>Erik J. Ragsdale, Manuela R. Mller, Christian Rdelsperger, Ralf J. Sommer <br /><br/>A Genetic Switch Coupled to Micro- and Macroevolution of a Developmental Plasticity Acts Through a Sulfatase <br /><i>Cell</i>, 7 November 2013 <br /></p> <br /><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body><html readability="51.9932761809"><head><title>1 worm, 2 mouths</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="Depending on the environment in which the worm grows, the larva of the roundworm Pristionchus pacificus develops into either a wide-mouthed predator or a narrow-mouthed bacteria eater. A team of researchers at the Max Planck Institute for Evolutionary Biology in Tbingen, Germany, headed by Ralf J. Sommer have now discovered a developmental biological switch that determines the worm's mouth form. "/><meta name="keywords" content="Biology Evolution"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Cell"/><meta name="type" content="research"/><meta name="institution" content="Max-Planck-Gesellschaft"/><meta name="meeting" content=""/><meta name="region" content="europe"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="128.504551585"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Erik Ragsdale<br/>erik.ragsdale@tuebingen.mpg.de<br/>49-070-716-01496<br/><span class="relinst">Max-Planck-Gesellschaft</span><br /><br /><br/></p><br /><h2 class="subtitle">A devious evolutionary path between genetics and environment</h2><br /><br /><!-- Begin image here --><br /><!-- End image here --><p>Depending on the environment in which the worm grows, the larva of the roundworm <i><i>Pristionchus</i> pacificus</i> develops into either a wide-mouthed predator or a narrow-mouthed bacteria eater. A team of researchers at the Max Planck Institute for Evolutionary Biology in Tbingen, Germany, headed by Ralf J. Sommer have now discovered a developmental biological switch that determines the worm's mouth form. According to this, the scientists are now able to explain how organisms adapt to different surrounding conditions.</p> <br /> <p>When it comes to survival, flexibility is a trump card. This principle also applies to the microscopic roundworm <i><i>Pristionchus</i> pacificus</i>, which is being researched by scientists at the Max Planck Institute for Developmental Biology in a study headed by Ralf Sommer. Depending on the environment in which <i>Pristionchus</i> grows, it develops either a short wide mouth or a long narrow one. The wide-mouthed variant, which has a single, characteristic tooth, is suitable for carrying out predatory attacks. The narrow version, in contrast, is mainly used for grazing on bacterial food sources. The developmental path taken by a <i>Pristionchus</i> larva is not decided by its genes but by the environment. When the animals were starved or when too many worms crowded the Petri dish, the researchers observed the increased development of the wide-mouthed variant.</p> <br /> <p>Erik Ragsdale, Manuela Mller, Christian Rdelsperger and Ralf Sommer have now discovered a crucial interface between the worm's environment and its developmental genes. The Tbingen-based scientists found a gene which functions like a switch and selects the suitable variant from the two possible mouth forms. </p> <br /> <p>The discovery of this gene was the crowning success of a genetic experiment, to which roundworms are particularly suited due to their short generation time. Ragsdale and Mller discovered mutated worm lines which only produce worms with narrow mouths, irrespective of the environmental conditions, and in which the same gene, eud-1, is inactivated. "We were able to show that a gene that we found in a genetic experiment under laboratory conditions controls an ecologically significant characteristic," comments Max Planck Director Sommer, explaining the special significance of this discovery.</p> <br /> <p>eud-1 is the gene for a sulfatase. Sulfatases are enzymes that chemically alter other proteins or molecules. The scientists in Tbingen do not yet know precisely which molecules are the targets of this special sulfatase. They presume, however, that eud-1 influences the characteristics of hormonal messenger substances. This would fit with their observation that eud-1 is mainly active in the worm's neurons where important messenger substances are produced.</p> <br /> <p>Armed with the information about the eud-1 mutants, Ragsdale and his colleagues crosschecked their findings and introduced additional copies of the eud-1 gene into <i>Pristionchus</i> worms using genetic engineering tricks. Almost all of these transgenic worms developed the wide mouth form with the characteristic tooth.</p> <br /> <p>eud-1 thus works like a train dispatcher at a large railway station who decides which platform a high-speed train can pull into based on the current traffic situation. During a critical phase in the worm's development, it follows the one-way track to a "wide mouth" or "narrow mouth".</p> <br /> <p>The capacity of many organisms to tailor their development to the changing demands of the environment is known as "phenotypic plasticity". The discovery of the des eud-1 gene is important because the molecular-genetic mechanisms that facilitate this plasticity in the animals have been largely unknown up to now. </p> <br /> <p>"Phenotypic plasticity is often referred to as an explanation for evolutionary adaptations to different environmental conditions. We provide an example of a genetic mechanism that enables such evolutionary bifurcations," says Sommer.</p> <br /> <p>Exactly how the environment and genes interact is a controversial topic among evolutionary biologists in certain respects. It is clear that the environment selects between genetically different variants this is Darwin's natural selection. However, researchers like American biologist Mary-Jane West-Eberhard claim that the environment can also directly influence the emergence of new phylogenetic characteristics.</p> <br /> <p>In the case of a "plastic" characteristic like the shape of the mouth aperture, external circumstances determine whether it presents in one form or another. West-Eberhard and other scientists suspect that a characteristic determined by the environment in this way can then become permanently defined at genetic level. Speciation or the division of species could even arise in this manner. However, this is little more than a controversial theory, for which hardly anything by way of experimental proof could be provided to date.</p> <br /> <p>With the discovery of the switch gene eud-1, the Max Planck scientists in Tbingen have identified a genetic mechanism that fits well with this hypothesis. Hence, complex evolutionary models with plasticity and environmental influences as driving forces may perhaps be more than controversial musings.</p> <br /> <p>###</p> <br /> <p><b>Original publication</b> <br /></p><p>Erik J. Ragsdale, Manuela R. Mller, Christian Rdelsperger, Ralf J. Sommer <br /><br/>A Genetic Switch Coupled to Micro- and Macroevolution of a Developmental Plasticity Acts Through a Sulfatase <br /><i>Cell</i>, 7 November 2013 <br /></p> <br /><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body></html>Source: <a href="http://www.eurekalert.org/pub_releases/2013-11/m-owt110713.php">http://www.eurekalert.org/pub_releases/2013-11/m-owt110713.php</a><br />Related Topics: <a href="http://www.tagzania.com/user/lured26/">PS4 release date</a> <a href="http://www.mycandylove.com/profil/EfrainKwiat">Susan Bennett</a> <a href="http://games.337.com/en/user/info/52318839">Spring High School</a> <a href="http://www.beckett.com/users/TamathabaChiehsitholm">Liam Payne</a> <a href="http://www.playedonline.com/users/revengeful39">miley cyrus</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-73948106910386367952013-11-07T18:18:00.001-08:002013-11-07T18:18:38.068-08:00TWITTER IPO LIVE: Contrasts near Twitter HQ<p>Specialist Glenn Carell, who will handle the Twitter IPO, works at his post on the floor of the New York Stock Exchange, Thursday, Nov. 7, 2013. Twitter set a price of $26 per share for its initial public offering on Wednesday evening and will begin trading Thursday under the ticker symbol "TWTR" in the most highly anticipated IPO since Facebook's 2012 debut. (AP Photo/Richard Drew)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Specialist Glenn Carell, who will handle the Twitter IPO, works at his post on the floor of the New York Stock Exchange, Thursday, Nov. 7, 2013. Twitter set a price of $26 per share for its initial public offering on Wednesday evening and will begin trading Thursday under the ticker symbol "TWTR" in the most highly anticipated IPO since Facebook's 2012 debut. (AP Photo/Richard Drew)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Twitter Chairman and co-founder Jack Dorsey, co-founders Biz Stone and Evan Williams and, Twitter CEO Dick Costolo pose for a group photo after their company's IPO began trading, on the floor of the New York Stock Exchange, Thursday, Nov. 7, 2013. If Twitter's bankers and executives were hoping for a surge on the day of the stock's public debut, they got it. The stock opened at $45.10 a share on its first day of trading, 73 percent above its initial offering price. (AP Photo/Richard Drew)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Twitter CEO Dick Costolo, Chairman and co-founder Jack Dorsey, and co-founders Evan Williams and Biz Stone, front row left to right, applaud as they watch the the New York Stock Exchange opening bell rung, Thursday, Nov. 7, 2013. If Twitter's bankers and executives were hoping for a surge on the day of the stock's public debut, they got it. The stock opened at $45.10 a share on its first day of trading, 73 percent above its initial offering price. (AP Photo/Richard Drew)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Twitter CEO Dick Costolo, center, and Mike Gupta, chief financial officer of Twitter, wait for shares to begin trading during the IPO, on the floor of the New York Stock Exchange, Thursday, Nov. 7, 2013. If Twitter's bankers and executives were hoping for a surge on the day of the stock's public debut, they got it. The stock opened at $45.10 a share on its first day of trading, 73 percent above its initial offering price. (AP Photo/Richard Drew)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Twitter signage is draped on the facade of the New York Stock Exchange, Thursday, Nov. 7, 2013 in New York. Twitter set a price of $26 per share for its initial public offering on Wednesday evening and will begin trading Thursday under the ticker symbol "TWTR" in the most highly anticipated IPO since Facebook's 2012 debut. (AP Photo/Mark Lennihan)</p><br /> <br /> <br /> <br /><br /><br /><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content"><span id="dateLine" class="dateline">NEW YORK</span> (AP) — Twitter had a strong public stock debut Thursday in the most highly anticipated initial public offering since Facebook's last year. That doesn't mean the people in the neighborhood near Twitter's headquarters are doing well.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter is trading under the ticker symbol "TWTR." Twitter's stock opened at $45.10, or 73 percent above its $26 IPO price. The opening price values Twitter at more than $31 billion based on its outstanding stock, options and restricted stock that'll be available after the IPO. Expect some changes throughout the day, though: It has traded as high as $50.09 and is now at $48.21.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The high price comes despite the fact that Twitter has never turned a profit in seven years of existence. Revenue has been growing, but the company is also investing heavily in more data centers and hiring more employees.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Here's a running account of Twitter's first day of trading, presented in reverse chronological order. All times are EST.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 3:05 p.m.: AP's @liedtkesfc explores the neighborhood outside @Twitter HQ and sees contrasts.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The San Francisco neighborhood outside Twitter's headquarters provides a forlorn contrast to the suddenly rich people working inside the building.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">These are among the meaner streets in downtown San Francisco, long populated with the destitute who have no place to live and the miscreants who resort to crime to make ends meet. In hopes of cleaning the area up, the city of San Francisco gave Twitter local tax breaks on employee stock options to help persuade the company to move into the neighborhood two years ago.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">But times are still tough here. Scruffy-looking people gathered against the wall of a post office across the street from Twitter's headquarters. Four of them had just spent the night in a homeless shelter. All of them said that they wished that they owned Twitter stock, yet they maintained that they didn't really envy Twitter employees becoming wealthier as the stock soared Thursday.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">There was a clump of litter just a few feet away. Amid the empty coffee cups, cigarette butts and empty liquor bottles, there were two scratch-off games for the California lottery that had been discarded because they didn't pay off. #LandofBrokenDreams</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Michael Liedtke, San Francisco, @liedtkesfc</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 2:50 p.m.: In Asia, @Twitter has competition from local companies, reports AP's @YKLeeAP</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Led by Japan, Indonesia, South Korea and India, Asia was the fastest growing region for Twitter in summer 2010, according to Semiocast, a Paris-based social media research company. But growth has slowed in South Korea and Japan, a red flag for Twitter as both countries are wealthy and have high rates of mobile device usage — now the predominant way Twitter is accessed.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">New mobile applications from companies such as South Korea's Kakao Corp. and Japan's Line Corp., have experienced explosive growth, making them potent competitors for eyeballs and advertising.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Why are people leaving Twitter or spending less time on it?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Too open. Too crowded. Too difficult.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">"In South Korea and Japan, open type social networking services like Twitter and Facebook are losing steam," said Justin Lee, an analyst of mobile messengers and games at BNP Paribas. "Closed social networking services where messages are shared among a small group of people will become more popular."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter remains blocked from China's vast market but another giant, India, is open to Twitter. It has amassed 27 million users there, according to Semiocast. Yet Twitter acknowledged in IPO filings that low use of smartphones in emerging markets such as India could hamper the ability of advertisers to deliver compelling advertisements and hurt its earnings potential.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">International users accounted for about three quarters of Twitter's members but only a quarter of revenue in the first nine months of this year. About 25 percent of Twitter's 232 million active users are in Asia.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Youkyung Lee, Seoul, South Korea, @YKLeeAP</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 2:30 p.m.: @Twitter now among the most valuable media companies, notes AP's @rnakashi</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Like Twitter, the other large media companies in the country rely to some extent on advertising revenue. As of mid-afternoon, Twitter's value is nearly $33 billion, after including options and restricted stock that'll be available after the IPO.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The market value of other media companies: CBS Corp., $34.7 billion; Discovery Communications Inc., $30 billion; Viacom Inc., $38.8 billion; The Walt Disney Co., $120 billion; Time Warner Inc. $60.3 billion.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ryan Nakashima, Los Angeles, @rnakashi</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 2:10 p.m.: @NYSEEuronext has congratulated @Twitter "on a successful #NYSEIPO! We're excited to be your partner."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 1:55 p.m.: Looking back at Twitter's IPO price, here are some quick facts from @Dealogic</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter priced its IPO at $26, raising $1.82 billion. If the offering's underwriters fully exercise their option to buy more shares, the IPO's value will rise to $2.09 billion. That would make it the second-largest Internet IPO by an American company on record, following Facebook Inc.'s $16 billion, but beating Google Inc.'s $1.92 billion.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The research firm Dealogic says Twitter's IPO is set to be the third-largest U.S.-listed IPO so far this year, behind Plains GP Holdings at $2.9 billion and Zoetis' $2.6 billion.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Including Twitter, U.S.-listed tech industry IPOs have raised $7.8 billion through 41 deals so far this year. That's down from $20.5 billion generated by 35 deals during the same period of 2012, though Facebook accounted for $16 billion of the 2012 total.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Tech companies tend to post bigger first-day jumps than the overall market. The average one-day jump for tech industry IPOs this year is 35 percent, compared with an average gain of 17 percent for 2013 IPOs overall. Twitter's stock opened at 73 percent above the IPO price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Bree Fowler, New York, @APBreeFowler</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 1:40 p.m.: @Twitter soars while drop in overall market pulls down rest of Internet cos.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter shares are flying high, but other Internet companies are having a tough time getting off the ground.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">While Twitter's debut likely helped send shares of Facebook Inc. down, the overall tech industry also took a hit as the markets pulled back from record levels on worries that the Federal Reserve could soon start curtailing its economic stimulus program.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Facebook shares fell $1.07, or 2.2 percent, to $48.05 after dropping as low as $47.41 earlier in the day. Other Internet companies such as LinkedIn Corp., AOL Inc., Google Inc., Pandora Media Inc. and Zillow Inc. all posted small to moderate losses.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Bree Fowler, New York, @APBreeFowler</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 1:20 p.m.: Will Twitter's stock keep going up? There is risk of Twitter burnout. #TwitterHaters</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">There's plenty of evidence online about the celebrities who tire of Twitter. The long list of Twitter quitters includes everyone from Alec Baldwin to Miley Cyrus to "Lost" co-creator Damon Lindelof, though some eventually return.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Some get overwhelmed by followers spewing hatred. Others get addicted to interacting with huge fan bases and need to pull away. Even non-celebrity users complain of the amount of time spent posting and replying and vow to close accounts to get on with their lives.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">With its public stock debut, the company has been selling potential investors on the idea that its user base of 232 million will continue to grow along with the 500 million tweets that are sent each day. The company's revenue depends on ads it inserts into the stream of messages.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">But Wall Street could lose its big bet on social media if prolific tweeters lose their voice.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Read more: http://bigstory.ap.org/article/user-burnout-could-threaten-twitters-prosperity</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ryan Nakashima, Los Angeles, @rnakashi</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 1:05 p.m.: Twitter chairman @jack makes reference to first tweet in Vine video post</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">About two hours ago, Twitter chairman and co-founder Jack Dorsey tweeted this: "just setting up our $twtr —https://vine.co/v/hI1nP3vQOBI" The link is to video on Twitter's Vine app, showing traders shouting on NYSE trading floor.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The tweet, of course, is a reference to the world's first tweet, which was sent by Dorsey on March 21, 2006, and read "just setting up my twttr." Dorsey uses "$twtr" in Thursday's post in a reference to the stock's ticker symbol. Putting a dollar sign before it is a common way to refer to stocks on Twitter.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Barbara Ortutay, New York, @BarbaraOrtutay</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 12:50 p.m.: @Twitter is trading very heavily in its first day on @NYSE.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">About 82 million shares of Twitter have exchanged hands already. To put that in perspective, Twitter only sold 70 million shares in its IPO. One way to think about it, every share issued in Twitter's IPO has been traded more than once, and the session isn't half over yet.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Of course, not every investor who got shares of Twitter at the $26 IPO price is selling Thursday. Many large institutional investors are buy-and-hold firms. If every investor had sold at the debut, the stock would not have opened at 73 percent above the IPO price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 12:35 p.m.: @TDAmeritrade official says stock debut is flawless</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">"It's gone on pretty flawlessly," says JJ Kinahan, chief strategist at online brokerage TD Ameritrade.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">For one, he says, the broader market's downturn isn't affecting Twitter much. Trading is also tight, rather than volatile, which indicates that people feel like it was "pretty fairly priced," he says.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Barbara Ortutay, New York, @BarbaraOrtutay</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 12:15 p.m.: Learn more about @vivienneharr, @sirpatstew and @bostonpolice official who rang @NYSEEuronext opening bell</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Crediting its success to its users, Twitter gave the honor of ringing Thursday's opening bell at the New York Stock Exchange to three high-profile tweeters: a child activist, a legendary British actor and a Boston Police official.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Nine-year-old Vivienne Harr used a lemonade stand to raise more than $100,000 to support efforts to eliminate child slavery around the world. Her pink lemonade, along with a ginger-infused version, is now being bottled and sold online. A portion of the profits is donated to groups that work toward ending child slavery. More than 22,000 people follow @vivienneharr on Twitter.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Patrick Stewart is known both for his Twitter presence and his stage and screen careers. His highest profile roles have included Captain Jean-Luc Picard in "Star Trek: The Next Generation" and Professor Charles Xavier in the "X-Men" movies. About 722,000 people follow @sirpatstew. Stewart tweeted a picture of himself on Halloween dressed as a lobster in a bathtub. It was retweeted nearly 39,000 times.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Cheryl Fiandaca has been chief of public information for the Boston Police Department since July 2012. Fiandaca spearheaded the department's social media efforts, and her department used Twitter to get information to the public in the aftermath of the Boston Marathon bombings. More than 266,000 people follow @bostonpolice.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Bree Fowler, New York, @APBreeFowler</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 11:55 a.m.: @Wedbush analyst @MichaelPachter says high debut price suggests #TwitterIPO was managed well.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Wedbush analyst Michael Pachter says the surge "clearly shows that demand exceeds supply of shares."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">"It's impossible to know what the real value is," he says.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Still, he acknowledges that the price is "pretty high" and not something he was expecting.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Barbara Ortutay, New York, @BarbaraOrtutay</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 11:45 a.m.: It's #BusinessAsUsual at @Twitter headquarters, though employees seem happy.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Although Twitter's fortunes are already soaring on Wall Street, there haven't been any audible whoops of joy emanating from the company's San Francisco headquarters yet. But almost every employee walking in and out of the building is grinning.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter seems to know that it needs to accelerate its revenue growth to support its lofty stock price. A few employees just came out to usher in a group of advertising agency representatives. #TheNewReality</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">--Michael Liedtke, San Francisco, @liedtkesfc</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 11:30 a.m.: @Barclays official in charge of stock debut speaks with AP's @KenSweet, admits being "a little nervous."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">It was the biggest IPO of the year for Glenn Carell, the Barclays Capital official in charge of Twitter's stock debut. He has been doing it for 21 years and says, "I was a little nervous, but it went well."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter hired Barclays to be its "designated market maker," which supervises the trading of a company's stock on the New York Stock Exchange. The IPO process itself was managed by three other investment banks.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 11:05 a.m.: RT @KenSweet: Twitter took a long time to open due to the deal size. Goldman also likes to take its time.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Goldman Sachs, Morgan Stanley and JPMorgan Chase are the three investment banks in charge of Twitter's IPO.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">After debuting at $45.10, the stock is now trading at $47.85, or 84 percent above the IPO price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:55 a.m.: AP's @BarbaraOrtutay notes that the $31 billion value puts Twitter in the ballpark of Yum Brands and Deere & Co.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">It's also slightly below State Street Corp.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:53 a.m.: The opening price values Twitter at $31.3 billion.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">To calculate its value, the AP is using 694.8 million shares that Twitter is expected to have outstanding after the IPO, counting restricted shares and stock options it plans to issue to employees. At the $26 IPO price, the value was more than $18 billion.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:51 a.m.: Twitter stock opens at $45.10, 73 percent above IPO price</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:50 a.m.: Range is now $45 to $45.25, or up to 74 percent above IPO price. Very close to debut.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: They're closing the book.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:45 a.m. AP's @KenSweet says current bid is $45.25. The debut is near in #TwitterIPO.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:40 a.m.: Patrick Stewart tweets on #Ring of opening bell as Twitter trade debut imminent.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @SirPatStew: Honored to join @ev @jack @biz @dickc & the @Twitter team at their historic IPO this morning. #Ring! pic.twitter.com/XaJpYW2kIh</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:35 a.m.: It's getting close to Twitter's stock debut. First indication for opening price is even narrower: $45.50-$46.50.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The high end would be 79 percent above its IPO price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:30 a.m.: AP's @KenSweet now says opening price narrowed: $45-$47.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">He reports: "This is a good sign. Could mean we're finding the right price. Progress."</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:20 a.m.: AP's @KenSweet says opening price is expected even higher: $43-$47.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The range for first indication means Twitter could start trading at up to 81 percent above its IPO price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:15 a.m.: RT @KenSweet: I've heard some traders mention that this may not open until 1030, maybe 11. But things are changing rapidly.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10:10 a.m.: AP market reporter @KenSweet explains the role @Barclays has in #TwitterIPO.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Trading for Twitter's stock is under the supervision of Barclays Capital. Twitter hired the bank to be its "designated market maker." A DMM supervises the trading of a company's stock. He or she is an experienced trader in charge of ensuring that buying and selling go smoothly. If trading becomes volatile, the DMM can step in and buy shares using his or her firm's own money.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">DMMs are especially important the day a company goes public, because the DMM coordinates between Twitter, the company's investment banks and NYSE's floor traders to get a stock trading. If technical problems arise, the NYSE uses DMMs to bypass electronic trading systems, allowing humans to trade a company's stock. That is not possible on all-electronic stock exchanges such as the Nasdaq, which had technical problems during Facebook's IPO last year.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Barclays' role as Twitter's DMM does not mean it is in charge of the entire IPO process. That role falls to Twitter's investment banks: Goldman Sachs, Morgan Stanley and JPMorgan Chase.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Read more: http://bigstory.ap.org/article/twitter-picks-barclays-coordinate-ipo-trading</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 10 a.m.: #TwitterIPO first indication for opening price: $42-46.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">That means Twitter could start trading at up to 77 percent above its IPO price. Trading is to begin soon as representatives from Barclays continue negotiations to find the right price.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 9:50 a.m.: With the #Ring of the #NYSEBell past, what will happen? @KenSweet reports.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Traders gather around Twitter's booth on the floor of the New York Stock Exchange. At Twitter's post, the company's "designated market maker" starts taking orders from the traders, who are representing dozens of firms and hundreds of investors.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The goal of the DMM, who used to be known as the NYSE's specialists, is to figure out what is the best price to start trading Twitter's shares.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Due to massive investor and media interest in Twitter, the actual negotiation over what are the right price for Twitter's now-public shares will take some time. It could take as little as 20 minutes, or it could take an hour. The NYSE wants to avoid the trading debacle that Nasdaq faced with last year's Facebook's IPO, so it's going to be careful.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Read more: http://bigstory.ap.org/article/going-public-how-twitters-ipo-will-work</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 9:40 a.m.: The market is open at @nyse, though Twitter's stock won't trade right away.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @NYSEEuronext: #RING! Markets OPEN. #NYSEBell has rung, now begins #TwitterIPO price discovery. Wait for it . pic.twitter.com/gPxGgB6QWa</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The opening bid is $35, reports AP's @KenSweet. It's the first indication of where the stock will open later in the morning.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">As the NYSE's opening bell was rung, the graphic below displayed the hashtag #Ring!</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Who rang the bell?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @NYSEEuronext: @Twitter owes success to its users, so gives #NYSEBell to @SirPatrickStew, @VivienneHarr & @Bostonpolice #TwitterIPO pic.twitter.com/fAprlGV8Vs</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Bree Fowler, New York, @APBreeFowler</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">__</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 9:25 a.m.: What's being said on Twitter? IPO is the 10th most popular trending topic in the U.S.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">IPO is behind Thanksgiving, Texas, NFL and #throwbackthursday.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Worldwide, it doesn't make into the Top 10. Nobel Prize-winning author Albert Camus does. It's his birthday, after all.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Barbara Ortutay, New York, @BarbaraOrtutay</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 9:05 a.m.: RT @KenSweet: Floor trader Kenneth Polcari thinks twitter's $26 share price is pretty fair. Doesn't expect it to double on the open.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 8:50 a.m.: Busy morning at @nyse trading floor, reports AP's @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: Orders for Twitter have been coming in since 8 am, floor trader Jonathan Corpina tells me. Very busy.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: Corpina expects a smooth opening. The NYSE does IPOs all the time, he says. The difference here is volume and media attention.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: Traders use these handheld wireless computers to send orders. Paper orders ended a long time ago: pic.twitter.com/bwz8UK4xcB</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 8:40 a.m.: Why Twitter went to @nyse. Pressure is on with opening bell less than an hour away. #lessonsfromFB</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter chose to go public on the NYSE over the all-electronic Nasdaq. One of the reasons why Twitter likely chose the NYSE over the Nasdaq has to do with problems Facebook faced with its Nasdaq-listed IPO last year. A glitch in Nasdaq's trading software led to trading delays and order failures on Facebook's first day of trading.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The NYSE isn't taking any chances with Twitter. The exchange tested its trading software on Oct. 26 to prepare for Twitter's debut. If the NYSE faces technical problems with its ordering software, the exchange can switch over the traditional human-based stock trading that dominated Wall Street for decades.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: NYSE traders and execs are really playing up the human element to this IPO. It's a shot across the bow at the Nasdaq.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Read more: http://bigstory.ap.org/article/twitter-list-new-york-stock-exchange</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Ken Sweet, New York, @KenSweet</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 8:20 a.m.: AP markets reporter @KenSweet says media outnumber traders 5:1 @nyse trading floor</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">It's a media madhouse. But it's still more than an hour before the opening bell, so more traders should be coming. Expect a big crowd.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">RT @KenSweet: The NYSE is decorated head to toe. with twitter logos. They went big here to promote: pic.twitter.com/pnwRQ9e6QG</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">___</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— 8 a.m.: After #TwitterIPO pricing, market debut comes Thursday.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">It should come as no surprise that Twitter used Twitter to announce its public stock debut.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">It began with a tweet on Sept. 12: The 7-year-old company posted on its official Twitter account that it has "confidentially submitted an S-1 to the SEC for a planned IPO." Details about offering emerged after the IPO documents were released publicly later.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">On Oct. 24, Twitter set its IPO price target at $17 to $20 per share. It raised that to $23 and $25 per share, signaling an enthusiastic response from prospective investors. The actual price on Wednesday night was even higher, at $26. That bodes well for the company's stock when trading begins.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Twitter also took to Twitter to announce that price: https://twitter.com/twitter/status/398235511254298624/photo/1</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">The company is offering 70 million shares in the IPO, plus an option to buy another 10.5 million. If all shares are sold, the IPO will raise $2.09 billion, making it the biggest IPO for an Internet company since Facebook raised $16 billion last year.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Of course, Facebook made its debut with high hopes, only to see its stock fall below the IPO price by the second day of trading. Twitter has valued itself at just a fraction of Facebook and sought to cool expectations in the months and weeks leading up to the offering.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">— Barbara Ortutay, New York, @BarbaraOrtutay</p><!-- SourceOrganizationStart --><span id="sourceOrganization" class="source-org vcard">Associated Press</span><!-- SourceOrganizationEnd -->Source: <a href="http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-11-07-Twitter%20IPO-Running/id-5f87c41248124d44bef6ca50e8343dab">http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-11-07-Twitter%20IPO-Running/id-5f87c41248124d44bef6ca50e8343dab</a><br />Similar Articles: <a href="http://www.pagodajunior.com/?document_srl=123519">julianne hough</a> <a href="http://www.pakmails.co/profile/scotty45e">politico</a> <a href="http://www.parklandcleaners.com/xe/?document_srl=409450">Bobby Cannavale</a> <a href="http://www.parkviewhills.ca/ru/index.php?a=stats&u=heribertomacred">brandon jacobs</a> <a href="http://www.partnerboersen-im-vergleich.de/top20/index.php?a=stats&u=christopersuq">Alison Pill</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-6401919256996318302013-11-07T18:13:00.001-08:002013-11-07T18:13:49.678-08:00Dan Henderson, Vitor Belfort granted TRT exemptions for UFN 32<div readability="52.6378433367"><br /><p><span><a class="sbn-auto-link" href="http://www.sbnation.com/mma/fight-card/142303/ufc-fight-night-32">UFC Fight Night 32</a> will feature the first MMA fight between athletes on testosterone-replacement therapy.</span></p><br /><p><span><a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122550/vitor-belfort">Vitor Belfort</a> and <a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122555/dan-henderson">Dan Henderson</a>, who meet on Nov. 9 in Goiania, Brazil, were granted the TRT exemptions for their light heavyweight contest for the main event. Brazilian MMA Athletic Commission’s (CABMMA) medical director, Dr. Marcio Tannure, told MMAFighting.com their exams were approved by the commission.</span></p><br /><p><a class="c1" href="http://www.mmajunkie.com/news/2013/11/vitor-belfort-dan-henderson-issued-trt-exemptions-for-ufc-fight-night-32">MMAJunkie</a> first reported the news.</p><br /><p><span>"They were already on treatment," Dr. Tannure told MMAFighting.com, "and CABMMA approved their exams to continue the treatment for this fight."</span></p><br /><p><span>According to Dr. Tannure, Belfort and Henderson are the only fighters on the card who required for an exemption to use the testosterone therapy.</span></p><br /><p><span>Belfort enters the cage after consecutive knockout victories over <a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122551/michael-bisping">Michael Bisping</a> and <a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122565/luke-rockhold">Luke Rockhold</a> in Brazil, while Henderson looks to get back to the win column following back-to-back split-decision losses to <a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122510/rashad-evans">Rashad Evans</a> and <a class="sbn-auto-link" href="http://www.sbnation.com/mma/fighter/122516/lyoto-machida">Lyoto Machida</a>.</span></p><br /></div>Source: <a href="http://www.mmafighting.com/2013/11/7/5078064/dan-henderson-vitor-belfort-granted-trt-exemptions-for-ufn-32">http://www.mmafighting.com/2013/11/7/5078064/dan-henderson-vitor-belfort-granted-trt-exemptions-for-ufn-32</a><br />Category: <a href="http://tiny.pl/qmv8t">Monster Mash</a> <a href="http://vtipy.vsetko.com/forum/profile.php?id=202038">Easy Halloween Costumes</a> <a href="http://wiki.edenpromise.org/FranceqaKenneallycx">Agents of SHIELD</a> <a href="http://www.almadangitme.net/wiki1/LouannbvRickertou">Polina Polonsky</a> <a href="http://www.amiciguatelli.it/nuke/modules.php?name=Your_Account&op=userinfo&username=RudyEEKO">backstreet boys</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-84483164602370864322013-11-07T18:09:00.001-08:002013-11-07T18:09:34.648-08:00Star Wars: Episode VII launch date confirmed for December 18th 2015<p>Sorry, Readability was unable to parse this page for content.</p>Source: <a href="http://www.engadget.com/2013/11/07/star-wars-episode-vii-launch-date-december-2015/?ncid=rss_truncated">http://www.engadget.com/2013/11/07/star-wars-episode-vii-launch-date-december-2015/?ncid=rss_truncated</a><br />Similar Articles: <a href="https://twitter.com/Rohil11sharma/status/392992036455870465">packers</a> <a href="https://twitter.com/rock8955/status/392995019486797824">Scott Eastwood</a> <a href="https://twitter.com/HadwinSmith1/status/392994980077133824">Léon Foucault</a> <a href="https://twitter.com/AileenRDania/status/392996334203977728">Washington Navy Yard</a> <a href="https://twitter.com/MohanSharmaa/status/392997739895603200">vince young</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-62895333678776953102013-11-07T13:36:00.001-08:002013-11-07T13:36:57.763-08:00GOP Succumbs to Governing by Anecdote<div id="article_body" readability="42.2912621359"><br /><p>It did not sound good for Sen. Pat Toomey.</p><br /><br /><p>“I’m a two-time breast cancer survivor and I’m facing the loss of insurance,” the Pennsylvania Republican declared Wednesday at a Senate Finance Committee hearing on the health-care law. “Three years ago, I was diagnosed with multiple sclerosis,” he added. “If my coverage is not in place before January 1st, I will have to go without my medications. This may cause permanent disability, blindness, inability to walk, speech problems.”</p><br /><br /><br/><br /></div>Source: <a href="http://www.realclearpolitics.com/2013/11/07/gop_succumbs_to_governing_by_anecdote_319428.html">http://www.realclearpolitics.com/2013/11/07/gop_succumbs_to_governing_by_anecdote_319428.html</a><br />Related Topics: <a href="http://www.shskytv.net/plus/guestbook.php">Dylan Penn</a> <a href="http://www.e-racun.hr/index.php?title=User:golf31sneeze">Sydney Leathers</a> <a href="http://www.e-racun.hr/index.php?title=Theimpressive_juice_beauty_organics_in_the_u.s.">september 11</a> <a href="http://occupedia.nl/index.php/Therevolutionary_juice_beauty_organics_in_the_world">miley cyrus</a> <a href="http://authoroo.com/business/home-based-business/thepreeminent-unconventional-juice-beauty-organics-in-the-united-states/">Breaking Bad Season 5 Episode 10</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-6707940188179216662013-11-07T13:33:00.001-08:002013-11-07T13:33:34.652-08:00Vivo Xplay review: $500 buys plenty of smartphone in China<img src="http://www.blogcdn.com/www.engadget.com/media/2013/10/dsc0378_thumbnail.jpg"/> A review of a smartphone that's primarily sold in China? Yes, that's exactly what this is, and with good reason. The Vivo Xplay merits attention because of the components it contains -- some of which are exotic, like its "HiFi grade" audio chips, and some of which are straightforward but desirable, ...<div class="feedflare"><br /><a href="http://feeds.engadget.com/~ff/weblogsinc/engadget?a=BHJizimV5dQ:oOhNnADfgNY:wF9xT3WuBAs"><img src="http://feeds.feedburner.com/~ff/weblogsinc/engadget?i=BHJizimV5dQ:oOhNnADfgNY:wF9xT3WuBAs" border="0"></img></a> <a href="http://feeds.engadget.com/~ff/weblogsinc/engadget?a=BHJizimV5dQ:oOhNnADfgNY:V_sGLiPBpWU"><img src="http://feeds.feedburner.com/~ff/weblogsinc/engadget?i=BHJizimV5dQ:oOhNnADfgNY:V_sGLiPBpWU" border="0"></img></a> <a href="http://feeds.engadget.com/~ff/weblogsinc/engadget?a=BHJizimV5dQ:oOhNnADfgNY:-BTjWOF_DHI"><img src="http://feeds.feedburner.com/~ff/weblogsinc/engadget?i=BHJizimV5dQ:oOhNnADfgNY:-BTjWOF_DHI" border="0"></img></a> <a href="http://feeds.engadget.com/~ff/weblogsinc/engadget?a=BHJizimV5dQ:oOhNnADfgNY:qj6IDK7rITs"><img src="http://feeds.feedburner.com/~ff/weblogsinc/engadget?d=qj6IDK7rITs" border="0"></img></a><br /></div><img src="http://feeds.feedburner.com/~r/weblogsinc/engadget/~4/BHJizimV5dQ" height="1" width="1"/>Source: <a href="http://feeds.engadget.com/~r/weblogsinc/engadget/~3/BHJizimV5dQ/">http://feeds.engadget.com/~r/weblogsinc/engadget/~3/BHJizimV5dQ/</a><br />Tags: <a href="http://urlquery.net/report.php?id=7471718">ny giants</a> <a href="http://flaker.pl/f/8497162-youtube.comwatch-blue-is-the-warmest-color-2013-full-movie-online">Ios 7 Jailbreak</a> <a href="http://www.darteros.com/notice/1723408">Arsenio Hall</a> <a href="http://moreofusthanyou.ning.com/profiles/status/show?id=6507498%3AStatus%3A239811">Obama Syria</a> <a href="http://theartsandmusic.com/profiles/status/show?id=3680536%3AStatus%3A319540">Madden 25</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-42466703345157180952013-11-07T13:29:00.001-08:002013-11-07T13:29:34.799-08:00Blocking the active site of thiolase<head><title>Blocking the active site of thiolase</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="Scientists at the University of Oulu, Finland, and at the HZB break new ground for drug discovery research in the fight against sleeping sickness Scientists at the University of Oulu, Finland, and at the Helmholtz Center Berlin have shown the way to new directions in drug development against African sleeping sickness and other tropical parasitic infections."/><meta name="keywords" content="Biology Biochemistry Parasitology Chemistry/Physics/Materials Sciences Biochemistry Medicine/Health Disease in the Developing World"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Biochemical Journal"/><meta name="type" content="research"/><meta name="institution" content="Helmholtz-Zentrum Berlin fr Materialien und Energie"/><meta name="meeting" content=""/><meta name="region" content="europe"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="102.066449688"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Dr. Manfred Weiss<br/>manfred.weiss@helmholtz-berlin.de<br/>49-308-062-13149<br/><span class="relinst">Helmholtz-Zentrum Berlin fr Materialien und Energie</span><br /><br /><br/></p><br /><h2 class="subtitle"/><br /><br /><p> <i> <b>This news release is available in German. </b> </i> </p> <!-- Begin image here --><br /><!-- End image here --><p>Scientists at the University of Oulu, Finland, and at the Helmholtz Center Berlin (HZB) have shown the way to new directions in drug development against African sleeping sickness and other tropical parasitic infections. This was based on the structural analysis of the enzyme thiolase, which plays a central role in lipid metabolism in the parasite that causes sleeping sickness. The researchers examined the biomolecule's structure at the MX beamline of electron storage ring, BESSY II, at the HZB. (<i>Biochemical J.</i> 2013, DOI: 10.1042/BJ20130669)</p> <br /> <p>Sleeping sicknesses african trypanosomiasis, kala-azar, indian leishmaniasis are infections caused by tropical parasites. Millions get sick from them each year and thousands end up dying. Anti-parasitic drugs are expensive and often have a host of unwanted side effects. In decades, there have been no new effective therapies. Reason enough for the World Health Organization (WHO) to consider research, which can lead to the development of new anti-parasitic drugs, a top priority.</p> <br /> <p>Now, Prof. Rik Wierenga and his team at Oulu University have paved the way for this type of research by shedding light on the structure of the enzyme thiolase. Thiolase figures prominently in parasitic lipid metabolism. According to Wierenga, "key is knowing the geometry of the enzyme's active site. This is the place where lipids that play a central role in parasitic metabolism attach and where chemical reactions that convert lipids into other substances take place." Which is why it's important to investigate the active site's structure and function: "It enables us to develop lipid-like substances that firmly attach to the active site and block it." The molecules that are involved represent the ideal starting points for new drug development.</p> <br /> <p>Studies at BESSY of the enzyme thiolase have yielded a highly detailed image of thiolase's active site. "We now have a much clearer idea of thiolase's role in all this," says Wierenga. "It would appear that the enzyme catalyzes the first step in the sterol biosynthesis pathway, which is important in a number of parasites."</p> <br /> <p>"The measurements of crystalline thiolase proteins we obtained at our MX beamline has helped to unravel the active site's geometry," says HZB's own Dr. Manfred Weiss. One particular region of the protein called the HDCF loop turns out to be key. The structure, which lies deep within thiolase's interior, was previously unknown. "Understanding the HDCF loop is the ideal starting point for the development of new anti-parasitic drugs," adds Wierenga.</p> <br /> <p>###</p> <br /> <p><b>Original publication:</b> <br /></p><p>Harijan, R.K., Kiema, T.R., Karjalainen, M.P., Janardan, N., Murthy, M.R., Weiss. M.S., Michels, P.A., Wierenga, R.K. (2013) Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. <i>Biochem J.</i>, 455, 119-130.</p> <br /> <p><b>Additional information:</b> <br /></p><p>Prof. Dr. Rik Wierenga <br /><br/>Biocenter Oulu, University of Oulu, Oulu, Finland <br /><br/>Fon: +35 829448119 rik.wierenga@oulu.fi <br /></p> <br /> <br /><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body><html readability="39.1283566058"><head><title>Blocking the active site of thiolase</title><meta http-equiv="content-type" content="text/html; charset=ISO-8859-1"/><meta name="description" content="Scientists at the University of Oulu, Finland, and at the HZB break new ground for drug discovery research in the fight against sleeping sickness Scientists at the University of Oulu, Finland, and at the Helmholtz Center Berlin have shown the way to new directions in drug development against African sleeping sickness and other tropical parasitic infections."/><meta name="keywords" content="Biology Biochemistry Parasitology Chemistry/Physics/Materials Sciences Biochemistry Medicine/Health Disease in the Developing World"/><meta name="date" content="Thu, 07 Nov 2013 05:00:00 GMT"/><meta name="funder" content=""/><meta name="journal" content="Biochemical Journal"/><meta name="type" content="research"/><meta name="institution" content="Helmholtz-Zentrum Berlin fr Materialien und Energie"/><meta name="meeting" content=""/><meta name="region" content="europe"/><meta name="MSSmartTagsPreventParsing" content="TRUE"/><link rel="stylesheet" type="text/css" href="http://www.eurekalert.org/eurekalert.css"/><link rel="SHORTCUT ICON" href="http://www.eurekalert.org/images/e-lert.ico"/><!-- Analytics disabled --></head><body class="release" id="readabilityBody" readability="102.066449688"><br /><br /><br /><img align="right" width="140" height="36" src="http://www.eurekalert.org/images/back2e.gif" border="0" alt="[ Back to EurekAlert! ]"/><br /><br /><p><strong class="relemb"><p>PUBLIC RELEASE DATE:</p> <p>7-Nov-2013</p></strong></p><br /><br />[<br /><br /><br /> | E-mail <br /><br />]<br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><p>Contact: Dr. Manfred Weiss<br/>manfred.weiss@helmholtz-berlin.de<br/>49-308-062-13149<br/><span class="relinst">Helmholtz-Zentrum Berlin fr Materialien und Energie</span><br /><br /><br/></p><br /><h2 class="subtitle"/><br /><br /><p> <i> <b>This news release is available in German. </b> </i> </p> <!-- Begin image here --><br /><!-- End image here --><p>Scientists at the University of Oulu, Finland, and at the Helmholtz Center Berlin (HZB) have shown the way to new directions in drug development against African sleeping sickness and other tropical parasitic infections. This was based on the structural analysis of the enzyme thiolase, which plays a central role in lipid metabolism in the parasite that causes sleeping sickness. The researchers examined the biomolecule's structure at the MX beamline of electron storage ring, BESSY II, at the HZB. (<i>Biochemical J.</i> 2013, DOI: 10.1042/BJ20130669)</p> <br /> <p>Sleeping sicknesses african trypanosomiasis, kala-azar, indian leishmaniasis are infections caused by tropical parasites. Millions get sick from them each year and thousands end up dying. Anti-parasitic drugs are expensive and often have a host of unwanted side effects. In decades, there have been no new effective therapies. Reason enough for the World Health Organization (WHO) to consider research, which can lead to the development of new anti-parasitic drugs, a top priority.</p> <br /> <p>Now, Prof. Rik Wierenga and his team at Oulu University have paved the way for this type of research by shedding light on the structure of the enzyme thiolase. Thiolase figures prominently in parasitic lipid metabolism. According to Wierenga, "key is knowing the geometry of the enzyme's active site. This is the place where lipids that play a central role in parasitic metabolism attach and where chemical reactions that convert lipids into other substances take place." Which is why it's important to investigate the active site's structure and function: "It enables us to develop lipid-like substances that firmly attach to the active site and block it." The molecules that are involved represent the ideal starting points for new drug development.</p> <br /> <p>Studies at BESSY of the enzyme thiolase have yielded a highly detailed image of thiolase's active site. "We now have a much clearer idea of thiolase's role in all this," says Wierenga. "It would appear that the enzyme catalyzes the first step in the sterol biosynthesis pathway, which is important in a number of parasites."</p> <br /> <p>"The measurements of crystalline thiolase proteins we obtained at our MX beamline has helped to unravel the active site's geometry," says HZB's own Dr. Manfred Weiss. One particular region of the protein called the HDCF loop turns out to be key. The structure, which lies deep within thiolase's interior, was previously unknown. "Understanding the HDCF loop is the ideal starting point for the development of new anti-parasitic drugs," adds Wierenga.</p> <br /> <p>###</p> <br /> <p><b>Original publication:</b> <br /></p><p>Harijan, R.K., Kiema, T.R., Karjalainen, M.P., Janardan, N., Murthy, M.R., Weiss. M.S., Michels, P.A., Wierenga, R.K. (2013) Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop. <i>Biochem J.</i>, 455, 119-130.</p> <br /> <p><b>Additional information:</b> <br /></p><p>Prof. Dr. Rik Wierenga <br /><br/>Biocenter Oulu, University of Oulu, Oulu, Finland <br /><br/>Fon: +35 829448119 rik.wierenga@oulu.fi <br /></p> <br /> <br /><hr/><img src="http://www.eurekalert.org/images/back2e.gif" align="right" width="140" height="36" border="0" alt="[ Back to EurekAlert! ]"/><br /><br />[<br /><br /><br /> | E-mail <br /><br /><!-- AddThis Button BEGIN --><br /><img src="http://www.eurekalert.org/images/share_icon.gif" width="11" height="11" border="0" alt="Share"/> Share<!-- AddThis Button END --><br /><br />]<br /><br /><p> <br /><br /></p><p class="disclaimer"><br/><em>AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.</em></p><br /><br /><br/><!-- footer block --></body></html>Source: <a href="http://www.eurekalert.org/pub_releases/2013-11/hbfm-bta110713.php">http://www.eurekalert.org/pub_releases/2013-11/hbfm-bta110713.php</a><br />Tags: <a href="http://sharesend.com/2y5rhxpk">Richie Incognito</a> <a href="https://app.box.com/s/7ts1tmpw6zdfeutxf139">fiona apple</a> <a href="https://app.box.com/s/psn9qfv0x0ax65e9cgm9">Michelle Rodriguez</a> <a href="http://www.247digitallearning.com/index.php/profile/quitleader64">Sons Of Anarchy Season 6</a> <a href="http://www.eve6.com/users/TbYWPFEp">Linda Ronstadt</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-73844954142109462252013-11-07T13:25:00.001-08:002013-11-07T13:25:37.368-08:00Google ordered by French court to block Max Mosley sex party photos<div id="main" role="main" itemscope="" itemtype="http://schema.org/Article" readability="120.871605589"><br /><br /><br /><br /><br /><p><span itemprop="articleBody description text">A French court has ordered Google to block from its search results pictures of former Formula One motor racing president Max Mosley participating in a sado-masochistic sex party with five women.</span></p><br /><p><span itemprop="articleBody description text">Google’s lawyers are still studying Wednesday’s ruling and plan to appeal. They say the Paris High Court wants the company to build a censorship machine.</span></p><br /><p><span itemprop="articleBody description text">The pictures were initially published under the headline “F1 BOSS HAS SICK NAZI ORGY WITH 5 HOOKERS” on March 30, 2008, by now-defunct British newspaper News of the World, which paid one of the women to record the event using a hidden video camera.</span></p><br /><p><span itemprop="articleBody description text">A <a href="http://www.bailii.org/ew/cases/EWHC/QB/2008/1777.html">subsequent court case found</a> that, while the video showed participants speaking German and wearing modern German military uniforms or playing the role of prisoners, there was no evidence of a Nazi theme. In the same ruling, the High Court of England and Wales found that the newspaper had infringed Mosley’s right to privacy and awarded him £60,000 (then $120,000) in damages.</span></p><br /><p><span itemprop="articleBody description text">Mosley has also had publication of the photos declared illegal in separate cases in France and Germany, according to a statement released by his U.K. lawyers, Collyer Bristow.</span></p><br /><p><span itemprop="articleBody description text">“This is a welcome decision. The action was brought in respect of a small number of specific images ruled illegal in the English and French courts several years ago. Despite their illegality and my repeated notifications to them, Google continued to make the images available on its own webpages,” Mosley said in the statement.</span></p><br /><p><span itemprop="articleBody description text">However, the company maintains that it has responded to Mosley’s notifications by removing links to the photos. <a href="http://googlepolicyeurope.blogspot.fr/2013/09/fighting-against-censorship-machine.html"/></span></p><br /><span itemprop="articleBody description text"><q>In the present case, Mosley had asked the Paris High Court to go further, banning Google from showing or linking to nine specific photos</q></span><br /><h2><span itemprop="articleBody description text">Can you erease an embarassing image?</span></h2><br /><p><span itemprop="articleBody description text">In the present case, Mosley had asked the Paris High Court to go further, banning Google from showing or linking to nine specific photos without waiting for notification about individual publications of them.</span></p><br /><p><span itemprop="articleBody description text">The court ordered that Google France and its U.S. parent company not show or link to the images for five years, or pay a €1,000 ($1,575) fine for each lapse. It is not clear whether the ruling, which Google has two months to implement, is intended to apply to Internet users outside France, and Google’s lawyers are still studying it.</span></p><br /><p><span itemprop="articleBody description text">“This is a troubling ruling with serious consequences for free expression and we will appeal it. Even though we already provide a fast and effective way of removing unlawful material from our search index, the French court has instructed us to build what we believe amounts to a censorship machine,” said Google Associate General Counsel Daphne Keller in a statement.</span></p><br /><p><span itemprop="articleBody description text">A company spokesman declined to answer further questions about the case.</span></p><br /><p><span itemprop="articleBody description text">Wednesday’s ruling only concerns Google, and will not affect the publishers of the Web pages carrying the images, which will remain online. Nor will it affect other search engines—and a rapid comparison with Microsoft’s Bing shows that it offers an equally comprehensive selection of links to the disputed images in its search results.</span></p><br /><div id="container-article-meta" class="c2" readability="5.72784810127"><br /><br /><div class="author-info" id="petersayeridgnewsservice" readability="8.69565217391"><br /><h3>Peter Sayer, IDG News Service <span>, IDG News Service</span></h3><br /><p>Peter Sayer covers open source software, European intellectual property legislation and general technology breaking news.<br/><strong>More by <a href="http://www.pcworld.com/author/Peter-Sayer/">Peter Sayer</a>, <a href="http://www.pcworld.com/author/IDG-News-Service/">IDG News Service</a></strong></p><br /></div><br /></div><br /><br /><div id="toaster"><br /><br /><br /><div id="toasterNewsletter"><br /><h4>Subscribe to the Best of PCWorld Newsletter</h4><br /><br /></div><br /></div><br /><br /><br /><br /><div id="emailModal" class="c3" readability="9"><br /><br /><p><br /><h2>Thank you for sharing this page.</h2><br /></p><br /><p><br /><h2>Sorry! There was an error emailing this page</h2><br /></p><br /></div><br /></div>Source: <a href="http://www.pcworld.com/article/2061920/google-ordered-by-french-court-to-block-max-mosley-sex-party-photos.html#tk.rss_all">http://www.pcworld.com/article/2061920/google-ordered-by-french-court-to-block-max-mosley-sex-party-photos.html#tk.rss_all</a><br />Category: <a href="http://verdexa.com/story.php?title=how-you-ll-be-able-to-proficiently-handle-your-time-with-earth-huge-net-marketing?729655926">snl</a> <a href="http://celestialbookmarks.com/tags.php/75976">remembering 9/11</a> <a href="http://skewbr.com/story.php?id=321424">"i Have A Dream" Speech</a> <a href="http://ihotinot.com/story.php?title=the-top-method-to-proficiently-deal-with-your-time-and-efforts-with-website-marketing-and-advertising?527556648">Linda Ronstadt</a> <a href="http://flyngi.com/tags.php/211695">Miley Cyrus Vma 2013</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-84212242480020015382013-11-07T13:20:00.001-08:002013-11-07T13:20:35.070-08:00Q&A on polonium: Swiss say Arafat was poisoned<p>Palestinians walk past a mural depicting late Palestinian leader Yasser Arafat at Shati Refugee Camp, in Gaza City, Thursday, Nov. 7, 2013. Swiss scientists have found evidence suggesting Yasser Arafat may have been poisoned with a radioactive substance, a TV station reported on Wednesday, prompting new allegations by his widow that the Palestinian leader was the victim of a "shocking" crime. Arabic reads, "the leader Abu Ammar, you are in our hearts, your sun will not go down." (AP Photo/Adel Hana)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Palestinians walk past a mural depicting late Palestinian leader Yasser Arafat at Shati Refugee Camp, in Gaza City, Thursday, Nov. 7, 2013. Swiss scientists have found evidence suggesting Yasser Arafat may have been poisoned with a radioactive substance, a TV station reported on Wednesday, prompting new allegations by his widow that the Palestinian leader was the victim of a "shocking" crime. Arabic reads, "the leader Abu Ammar, you are in our hearts, your sun will not go down." (AP Photo/Adel Hana)</p><br /> <br /> <br /> <br /><br /><br /><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content"><span id="dateLine" class="dateline">LONDON</span> (AP) — The deadly radioactive element polonium first hit the headlines when it was used to kill KGB agent-turned-Kremlin critic Alexander Litvinenko in London in 2006.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Scientists at Switzerland's Institute of Radiation Physics said Thursday they've found evidence that Palestinian leader Yasser Arafat was deliberately poisoned with polonium though they don't know if it ultimately killed him.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Arafat died under mysterious circumstances at a French military hospital in 2004 but the Swiss say the amounts of polonium and its byproducts, including lead, that they found in his bones and grave soil could not have been accidental.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Other scientists said the Swiss results were suggestive of poisoning but not definite proof. The Swiss have countered that it might be impossible to get definitive proof since the tests were conducted years after Arafat's death.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Here are some facts about polonium.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHAT IS POLONIUM?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Polonium-210 is one of the world's rarest elements, discovered in 1898 by scientists Marie and Pierre Curie and named in honor of her country of origin, Poland. It occurs naturally in very low concentrations in the Earth's crust and also is produced artificially in nuclear reactors. In small amounts, it has legitimate industrial uses, mainly in devices to eliminate static electricity. Polonium is not naturally found in the human body.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">HOW DANGEROUS IS IT?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Very. If ingested, it is lethal in extremely small doses. A minuscule amount of the silver powder is sufficient to kill. British radiation experts say once polonium-210 enters the bloodstream, its deadly effects are nearly impossible to stop.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHERE DOES IT COME FROM?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Polonium can be a byproduct of the chemical processing of uranium, but usually it's made artificially in a nuclear reactor or a particle accelerator. Dozens of countries including Russia, Israel and the U.S. have the nuclear capability to produce polonium. Derek Hill, a radiation expert at University College London, said if there was enough polonium left in the Arafat samples, it might be possible to trace where the element came from — providing more clues about whether Arafat was poisoned.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">IS IT UNUSUAL TO FIND POLONIUM IN PEOPLE?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Yes. Alastair Hay, a professor of environmental toxicology at the University of Leeds, said there is no natural amount of polonium you would expect to find in someone — unless they worked in atomic energy plants or dealt with radioactive isotopes. He said it was difficult to explain why Arafat's body had any traces of it.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">HOW CAN IT POISON PEOPLE?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">People can be poisoned if they eat or drink food contaminated with polonium, breathe air contaminated with it or get it in an open wound. Litvinenko apparently drank tea laced with polonium during a meeting at a London hotel.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">CAN SCIENTISTS PROVE THAT ARAFAT WAS POISONED?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Absolute proof is elusive. There have been so few cases of known polonium poisoning that scientists don't know very much about its exact symptoms. Swiss scientists say Arafat had symptoms commonly linked to radiation poisoning, including nausea, vomiting, diarrhea and liver and kidney failure — but not two other classic symptoms, hair loss and a weaker immune system. The Swiss scientists also noted their tests faced several limitations. They had to perform their analyses on very small specimens — such as a single hair shaft or traces of blood and urine. Those tests were also conducted eight years after Arafat's death, so there could have been problems with chemical degradation.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHO HAS DIED FROM IT?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">In addition to Litvinenko's presumed death from polonium poisoning, some speculate that the Curies' daughter Irene, who died of leukemia, may have developed the disease after accidentally being exposed to polonium in the laboratory. Israeli author Michal Karpin has claimed the cancer deaths of several Israeli scientists were the result of a polonium leak at the Weizmann Institute of Science in 1957. Israeli officials have never acknowledged a connection.</p><!-- SourceOrganizationStart --><span id="sourceOrganization" class="source-org vcard">Associated Press</span><!-- SourceOrganizationEnd -->Source: <a href="http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-11-07-Polonium%20QandA/id-8688f95fdbbe40ca8b23f2f5c4a1d59f">http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2013-11-07-Polonium%20QandA/id-8688f95fdbbe40ca8b23f2f5c4a1d59f</a><br />Category: <a href="http://pinterestclones.com/pinterest-news/story.php?title=spin-rewriter">oakland raiders</a> <a href="http://bookmarkcity.me/story.php?title=spin-rewriter-2">Ios 7 Jailbreak</a> <a href="http://pornoforum.us/story.php?title=article-spinning">emily blunt</a> <a href="http://recomiendaesto.com/story.php?title=spin-rewriter-2">Selena Gomez</a> <a href="http://postsclassifieds.com/story.php?title=article-spinning-software">Zayn Malik</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-56791168739495612232013-11-07T13:12:00.001-08:002013-11-07T13:12:35.133-08:00Internet Explorer 11 comes to Windows 7 in its final form, brings speed improvements<div itemprop="text" readability="52.796474359"><br /><p class="image-container c1"><a href="http://www.engadget.com/2013/11/07/internet-explorer-11-comes-to-windows-7-in-its-final-form/"><img alt="Internet Explorer 11 comes to Windows 7 in its final form, brings speed improvements" src="http://www.blogcdn.com/www.engadget.com/media/2013/09/always-refresh-from-server-option-250-wide.jpg"/></a></p><br /><p>Internet Explorer has already been available on Windows 7 as an optional <a href="http://www.engadget.com/2013/09/18/ie11-for-windows-7-release-preview-available-now/">Release Preview</a>, but now it's making its way to the aging OS in a more complete form. Starting today, you can download the final build, which for all intents and purposes is identical to the version that recently shipped on <a href="http://www.engadget.com/2013/06/26/windows-8-1-hands-on/">Windows 8.1</a>. In fact, Rob Mauceri, Group Program Manager for Internet Explorer, tells us the company "began with a plan to align releases," and that the Windows 7 and 8.1 versions were developed at the same time. (That also explains why Win 7 users have lately been getting these updates soon after the Windows 8 crowd.)</p><br /><p>In case you need a recap, Internet Explorer brings some security and performance improvements, along with features like Pre-fetch and Pre-render for faster load times. Also, Microsoft improved on the "<a href="http://www.engadget.com/2012/05/31/windows-8-release-preview-detailed-impressions/">Flip Ahead</a>" feature introduced in IE10 so that now, when you move forward to the next page in a story, IE will keep the previous page around in case you want to click back to it. If you like, you can download Internet Explorer 11 now, or if you're the estimated 90 percent of users who allow Windows to install updates without asking, then you don't need to do a thing.</p><br /><div class="post-gallery"><br /><h3 class="title">Internet Explorer 11 for Windows 7</h3><br /><a class="more gallery-link" href="http://www.engadget.com/gallery/internet-explorer-11-for-windows-7">See all photos</a><br /><p class="photo-number">10 Photos</p><br /><br /></div><br /></div>Source: <a href="http://www.engadget.com/2013/11/07/internet-explorer-11-comes-to-windows-7-in-its-final-form/?ncid=rss_truncated">http://www.engadget.com/2013/11/07/internet-explorer-11-comes-to-windows-7-in-its-final-form/?ncid=rss_truncated</a><br />Related Topics: <a href="http://www.aradiginhersey.com/story.php?id=695200">Elizabeth Vargas</a> <a href="http://www.linkegit.net/story.php?title=turn-your-existing-garage-into-something-useful">torrie wilson</a> <a href="http://urock365.com/blogs/3459/5984/convert-your-garage-into-somethi">Alexian Lien</a> <a href="http://renagademedia.com/blogs/entry/Make-Your-Garage-Into-Your-Own-Lifestyle-Facility">Tami Erin</a> <a href="http://www.ochoasfamily.com/wiki/index.php?title=Tax_Tips_for_Internet_Marketers">Disney Infinity</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-11446522822297585002013-11-07T13:03:00.001-08:002013-11-07T13:03:51.019-08:00Q&A on polonium: Swiss say Arafat was poisoned<p>Palestinians walk past a mural depicting late Palestinian leader Yasser Arafat at Shati Refugee Camp, in Gaza City, Thursday, Nov. 7, 2013. Swiss scientists have found evidence suggesting Yasser Arafat may have been poisoned with a radioactive substance, a TV station reported on Wednesday, prompting new allegations by his widow that the Palestinian leader was the victim of a "shocking" crime. Arabic reads, "the leader Abu Ammar, you are in our hearts, your sun will not go down." (AP Photo/Adel Hana)</p><br /> <br /> <br /> <br /> <br /> <br /> <p>Palestinians walk past a mural depicting late Palestinian leader Yasser Arafat at Shati Refugee Camp, in Gaza City, Thursday, Nov. 7, 2013. Swiss scientists have found evidence suggesting Yasser Arafat may have been poisoned with a radioactive substance, a TV station reported on Wednesday, prompting new allegations by his widow that the Palestinian leader was the victim of a "shocking" crime. Arabic reads, "the leader Abu Ammar, you are in our hearts, your sun will not go down." (AP Photo/Adel Hana)</p><br /> <br /> <br /> <br /><br /><br /><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content"><span id="dateLine" class="dateline">LONDON</span> (AP) — The deadly radioactive element polonium first hit the headlines when it was used to kill KGB agent-turned-Kremlin critic Alexander Litvinenko in London in 2006.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Scientists at Switzerland's Institute of Radiation Physics said Thursday they've found evidence that Palestinian leader Yasser Arafat was deliberately poisoned with polonium though they don't know if it ultimately killed him.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Arafat died under mysterious circumstances at a French military hospital in 2004 but the Swiss say the amounts of polonium and its byproducts, including lead, that they found in his bones and grave soil could not have been accidental.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Other scientists said the Swiss results were suggestive of poisoning but not definite proof. The Swiss have countered that it might be impossible to get definitive proof since the tests were conducted years after Arafat's death.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Here are some facts about polonium.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHAT IS POLONIUM?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Polonium-210 is one of the world's rarest elements, discovered in 1898 by scientists Marie and Pierre Curie and named in honor of her country of origin, Poland. It occurs naturally in very low concentrations in the Earth's crust and also is produced artificially in nuclear reactors. In small amounts, it has legitimate industrial uses, mainly in devices to eliminate static electricity. Polonium is not naturally found in the human body.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">HOW DANGEROUS IS IT?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Very. If ingested, it is lethal in extremely small doses. A minuscule amount of the silver powder is sufficient to kill. British radiation experts say once polonium-210 enters the bloodstream, its deadly effects are nearly impossible to stop.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHERE DOES IT COME FROM?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Polonium can be a byproduct of the chemical processing of uranium, but usually it's made artificially in a nuclear reactor or a particle accelerator. Dozens of countries including Russia, Israel and the U.S. have the nuclear capability to produce polonium. Derek Hill, a radiation expert at University College London, said if there was enough polonium left in the Arafat samples, it might be possible to trace where the element came from — providing more clues about whether Arafat was poisoned.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">IS IT UNUSUAL TO FIND POLONIUM IN PEOPLE?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Yes. Alastair Hay, a professor of environmental toxicology at the University of Leeds, said there is no natural amount of polonium you would expect to find in someone — unless they worked in atomic energy plants or dealt with radioactive isotopes. He said it was difficult to explain why Arafat's body had any traces of it.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">HOW CAN IT POISON PEOPLE?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">People can be poisoned if they eat or drink food contaminated with polonium, breathe air contaminated with it or get it in an open wound. Litvinenko apparently drank tea laced with polonium during a meeting at a London hotel.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">CAN SCIENTISTS PROVE THAT ARAFAT WAS POISONED?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">Absolute proof is elusive. There have been so few cases of known polonium poisoning that scientists don't know very much about its exact symptoms. Swiss scientists say Arafat had symptoms commonly linked to radiation poisoning, including nausea, vomiting, diarrhea and liver and kidney failure — but not two other classic symptoms, hair loss and a weaker immune system. The Swiss scientists also noted their tests faced several limitations. They had to perform their analyses on very small specimens — such as a single hair shaft or traces of blood and urine. Those tests were also conducted eight years after Arafat's death, so there could have been problems with chemical degradation.</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">WHO HAS DIED FROM IT?</p><p class="ap_para ap_para-d57851005a80479aaeeb90a12c70b9f6 entry-content">In addition to Litvinenko's presumed death from polonium poisoning, some speculate that the Curies' daughter Irene, who died of leukemia, may have developed the disease after accidentally being exposed to polonium in the laboratory. Israeli author Michal Karpin has claimed the cancer deaths of several Israeli scientists were the result of a polonium leak at the Weizmann Institute of Science in 1957. Israeli officials have never acknowledged a connection.</p><!-- SourceOrganizationStart --><span id="sourceOrganization" class="source-org vcard">Associated Press</span><!-- SourceOrganizationEnd -->Source: <a href="http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-11-07-Polonium%20QandA/id-8688f95fdbbe40ca8b23f2f5c4a1d59f">http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-11-07-Polonium%20QandA/id-8688f95fdbbe40ca8b23f2f5c4a1d59f</a><br />Related Topics: <a href="http://ttlink.com/notice/5694847">red sox</a> <a href="http://alessandrobechardgwapo.cuzo.com/whats-the-number-1-means-to/">denver broncos</a> <a href="http://www.plurk.com/p/jckpbc">seattle seahawks</a> <a href="http://public.sitejot.com/iyaporesd.html">the league</a> <a href="http://meemi.com/angnamer/11427033">Jenna Wolfe</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-85448341203277046372013-11-07T12:57:00.001-08:002013-11-07T12:57:35.886-08:002014 will be the year of data<div itemprop="articleBody" readability="81.6046446558"><br /><div id="blog-edit" class="c5"><img src="http://www.infoworld.com/sites/infoworld.com/files/media/image/data_world.jpg" alt="2014 will be the year of data" width="243" height="182" align="right"/><p class="c4"><em>Credit: iStockphoto</em></p><br /></div><br /><p>The Harvard Business Review devoted its entire September issue to big data, rightfully focusing on <a href="http://www.infoworld.com/d/big-data/download-the-hadoop-deep-dive-210169?source=ifwelg">Hadoop</a>. Inside, the data scientist was anointed as the job of the future and experts dispensed advice on how to bring big data technologies to your company.</p><br /><p>As someone who started his <a href="http://www.osintegrators.com">own business</a> and grew it into a multi-million-dollar concern, I am a frequent reader of HBR. I don't have a business degree. I learned what I know from watching others and as a result of a life-long, debilitating, compulsive reading disorder (which I blame for my early-onset <a href="http://en.wikipedia.org/wiki/Presbyopia" target="_blank">presbyopia</a>, a disease of the eyes that means you're really old). It isn't common for HBR to be ahead of the curve on technology -- and it isn't often I read about a relatively new open source project like Hadoop in its pages.</p><br /><p><strong>[ Also on InfoWorld: <a href="http://www.infoworld.com/t/hadoop/hadoop-2-big-datas-big-leap-forward-228909?source=fssr">Hadoop 2: Big data's big leap forward</a>. | <a href="http://www.infoworld.com/d/big-data/download-the-hadoop-deep-dive-210169?source=ifwelg_fssr">Download the Hadoop Deep Dive</a> to learn how it works and the ways you can reap its benefits. | Keep up with the latest developer news with InfoWorld's <a href="http://www.infoworld.com/newsletters/subscribe?showlist=infoworld_developer&source=ifwelg_fssr">Developer World newsletter</a>. ]</strong></p><br /><p>According to Gartner, big data is expected to drive $34 billion of IT spending in 2013, with some predicting that number will more than triple by 2018. This year, amazingly, we also learned that the NSA is already a major user of big data technologies and has been for years. The government may not be able to deploy a <a href="http://www.infoworld.com/t/e-government/how-federal-cronies-built-and-botched-healthcaregov-228724">website that allows us to buy health insurance</a>, but when it comes to building a massive domestic surveillance network, that's done.</p><br /><p>We also saw 10gen change its name to MongoDB, acquire a <a href="http://www.infoworld.com/d/application-development/why-mongodb-worth-12-billion-228510">$1.2 billion valuation</a>, and break the nine-figure funding mark that means you're probably going for IPO rather than acquisition. In the big data space, there was plenty of money to go around: $50 million to Hortonworks, $45 million to DataStax, $25 million to Couchbase, and so on. </p><br /><p>In the last few years we've seen these technologies developed and deployed mainly by the "have tos" -- those companies with unprecidented data and usage problems, giants like Facebook, Yahoo, Twitter, or LinkedIn. While those companies may sit on more data and concurrent usage than some countries, they're often perceived as trendy or preoccupied with noncritical data -- hardly role models for mainstream businesses.</p><br /><p>More recently, though, those of us in the trenches have seen even some of our more conservative clients stop kicking the tires and start adopting NoSQL technologies, especially MongoDB. In 2013, "log analysis" emerged as the killer app for Hadoop and the pilot project of the year, we're beginning to see more serious thought put into not just the solutions, but in developing the right questions to ask.</p><br /><p>This phenomenon isn't localized, it's global. I write this from Brazil where a key-value store is being deployed to improve throughput in a large data project. Big data solutions may have begun by addressing problems in social media and entertainment, but they are spreading to education, health care, and finance.</p><br /><p>The momentum I've watched over the last year has been breathtaking. In 2014, even the more conservative IT departments are going to force their local Oracle sales rep into some very uncomfortable conversations -- that is, if the rep hasn't <a href="http://www.linkedin.com/vsearch/p?title=sales&openAdvancedForm=true&titleScope=CP&locationType=I&countryCode=us&orig=FCTD&rsid=1139181383707175457&f_N=F,S,A&openFacets=N,G,CC,PC&f_PC=1028" target="_blank">already quit and gone to one of the big data vendors</a>.</p><br /><p><em>This article, "<a href="http://www.infoworld.com/d/application-development/2014-will-be-the-year-of-data-230094?source=footer">2014 will be the year of data</a>," was originally published at <a href="http://www.infoworld.com/?source=footer">InfoWorld.com</a>. Keep up on the latest developments in <a href="http://www.infoworld.com/d/application-development?source=footer">application development</a>, and read more of <a href="http://www.infoworld.com/blogs/andrew-oliver?source=footer">Andrew Oliver's Strategic Developer blog</a> at InfoWorld.com. For the latest business technology news, follow <a href="http://twitter.com/infoworld" target="_blank">InfoWorld.com on Twitter</a>.</em></p><br /></div>Source: <a href="http://akamai.infoworld.com/d/application-development/2014-will-be-the-year-of-data-230094?source=rss_infoworld_top_stories_">http://akamai.infoworld.com/d/application-development/2014-will-be-the-year-of-data-230094?source=rss_infoworld_top_stories_</a><br />Similar Articles: <a href="http://neuehobby.com/Nieuwe_Hobby/Nieuwe_Hobby_Blog/view.php">Ian Somerhalder</a> <a href="http://support.oasys.us/modules.php?name=Your_Account&op=userinfo&username=ElishaUpa">liberace</a> <a href="http://thai-indochina.net/modules.php?name=Your_Account&op=userinfo&username=NataliaIu">Henry Blackaby</a> <a href="http://www.bcs-seo.com/austin-seo-blog/trackback_popup.php?id=48">fox sports</a> <a href="http://www.bmwe36blog.com/honda-mugen-s2000-is-being-beaten-to-death-by-a-m3.html">Linda Ronstadt</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-90461995961753676172013-11-07T12:52:00.001-08:002013-11-07T12:52:01.871-08:00Company restocking lifted US economic growth in Q3<figure class=" cover get-lbdata-from-dom go-to-slideshow-lightbox " data-id="cf1e3035-a0bb-3961-8e50-c7db0dfa2c37"><br /> <br /> <br /> </figure><p>FILE - In this Tuesday, July 16, 2013, file photo, a covered vehicle sits in part of the new paint shop at Chrysler's Sterling Heights Assembly Plant in Sterling Heights, Mich. The Commerce Department issues its first estimate of how fast the U.S. economy grew in the July-September quarter on Thursday, Nov. 7, 2013. (AP Photo/Paul Sancya, File)</p><br /> <br /> <br /> <br /> <!-- google_ad_section_start --><br /> <meta itemprop="datePublished" content="2013-11-07T14:45:52Z"/><meta itemprop="headline" content="Company restocking lifted US economic growth in Q3"/><meta itemprop="alternativeHeadline" content=""/><meta itemprop="image" content="http://media.zenfs.com/en_us/News/ap_webfeeds/352c40e18b446725420f6a7067001519.jpg"/><meta itemprop="description" content="WASHINGTON (AP) — The U.S. economy expanded at a 2.8 percent annual rate from July through September, a surprising acceleration ahead of the 16-day partial government shutdown. But much of the strength came from a buildup in company stockpiling."/><p>WASHINGTON (AP) — The U.S. economy expanded at a 2.8 percent annual rate from July through September, a surprising acceleration ahead of the 16-day partial government shutdown. But much of the strength came from a buildup in company stockpiling.</p><p>Home construction also rose, and state and local governments spent at their fastest pace in four years. But businesses spent less on equipment, federal spending fell and consumers spent at a slower pace. All are cautionary signs for the final three months of the year.</p><p>Overall, growth increased in the third quarter from a 2.5 percent annual rate in the April-June period to the fastest pace in a year, the Commerce Department said Thursday.</p><p>The third-quarter growth was nearly a full percentage point stronger than most economists had predicted. Analysts noted that much of the unforeseen strength came from a buildup in company inventories. That suggests that businesses overestimated consumer demand.</p><p>Restocking contributed 0.8 percentage point to growth — double its contribution in the second quarter.</p><p>Sal Guatieri, an economist at BMO Capital Markets, predicts that companies will cut back on restocking in the October-December quarter. He thinks less stockpiling, along with the effects of the shutdown, will slow growth to an annual rate below 2 percent this quarter.</p><p>Consumers stepped up spending on goods last quarter, but the pace of their increase weakened to a 1.5 percent annual rate from a 1.8 percent rate in the previous quarter. Spending on services was essentially flat, partly because of a cooler summer that lowered utility spending.</p><p>Spending by consumers is critical to growth because it drives roughly 70 percent of economic activity. Higher taxes this year and slow wage growth have weighed on consumers since the start of the year.</p><p>Exports rose at a 4.5 percent rate in the third quarter, helped by stronger economies overseas. Still, businesses cut back on investment in equipment by the most in a year.</p><p>Overall government activity grew at a slight 0.2 percent rate, reflecting a 1.5 percent rise in state and local government spending — the best showing since the spring of 2009. Federal government spending dropped again, falling at a 1.7 percent annual rate.</p><p>Analysts say the shutdown could cut more than half a percentage point from annual growth in the October-December quarter. The shutdown cost the U.S. economy an estimated $24 billion, according to Beth Ann Bovino, an economist at Standard & Poor's.</p><ul id="topics" class="hidden"><li data-id="YCT:001000663">Budget, Tax & Economy</li><li data-id="YCT:001000661">Politics & Government</li></ul><!-- google_ad_section_end -->Source: <a href="http://news.yahoo.com/company-restocking-lifted-us-economic-growth-q3-144126670--finance.html">http://news.yahoo.com/company-restocking-lifted-us-economic-growth-q3-144126670--finance.html</a><br />Similar Articles: <a href="http://jakiezdjecia.dreamwidth.org">Trick or Treat</a> <a href="http://fotoman.unblog.fr">bcs rankings</a> <a href="http://oslubie.tumblr.com">Johnny Manziel</a> <a href="http://zdjeciajakubi.canalblog.com">glee</a> <a href="http://nl.netlog.com/christinemaughan/blog">blobfish</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-84056238628126567202013-11-07T12:44:00.001-08:002013-11-07T12:44:39.873-08:00Dell's Venue 11 Pro tablet now available in the US, starts at $500 with Bay Trail inside<div itemprop="text" readability="35.3361945637"><br /><p class="image-container c1"><a href="http://www.engadget.com/2013/11/07/dell-venue-11-pro-tablet-launches-in-the-us/"><img alt="Dell's Venue 11 Pro tablet launches in the US, starting at $500" data-src-height="410" data-src-width="618" src="http://www.blogcdn.com/www.engadget.com/media/2013/11/dell-venue-11-pro-618.jpg"/></a></p><br /><p>After some mystery surrounding an American release date, Dell's <a href="http://www.engadget.com/2013/10/02/dell-venue-pro-8-and-pro-11-hands-on/">Venue 11 Pro</a> is now <a href="http://www.dell.com/us/p/dell-venue-11-pro/pd?oc=ftcwd02h&model_id=dell-venue-11-pro">available</a> in the US. The 10.8-inch <a href="http://www.engadget.com/2013/06/26/windows-8-1-hands-on/">Windows 8.1</a> tablet starts at $500 with a modest, <a href="http://www.engadget.com/2013/09/11/intel-announces-new-bay-trail/">Bay Trail</a>-based 1.5GHz Atom chip as well as 2GB of RAM and 64GB of storage. Those who need more processing grunt can step up to models with <a href="https://www.google.com/url?q=http://www.engadget.com/2013/07/23/intel-fanless-y-series-core-chips/&sa=U&ei=x617UuDELMb1qAG6lYGgCw&ved=0CAgQFjAA&client=internal-uds-cse&usg=AFQjCNHqlm3QeF5wQHIvha60rxsUvDweAg">Y-series</a> Core i3 and i5 chips that respectively cost $800 and $850; both of them also carry much roomier 128GB flash drives. Only WiFi slates are on sale, although a tipster tells us that there will be LTE-equipped versions. Just be prepared to wait if you want a Venue 11 Pro to call your own -- orders placed on launch day won't ship until December 5th at the earliest.</p><br /><p>[Thanks, anonymous]</p><br /></div>Source: <a href="http://www.engadget.com/2013/11/07/dell-venue-11-pro-tablet-launches-in-the-us/?ncid=rss_truncated">http://www.engadget.com/2013/11/07/dell-venue-11-pro-tablet-launches-in-the-us/?ncid=rss_truncated</a><br />Tags: <a href="http://youmob.com/mob.aspx?mob=http://seo.socialbookmarkings.net/story.php?title=how-to-make-money-on-the-internet-by-learning-ways-to-construct-internet-traffic">Austin Mahone</a> <a href="https://kippt.com/restrene9/list/clips/17466553">Gta 5 Online Not Working</a> <a href="http://www.plurk.com/p/j903nu">Brynn Cameron</a> <a href="http://www.thisnext.com/item/1D7249D8/BE0CB401/Ways-To-Earn-Money-On-The?share=1">Kenichi Ebina</a> <a href="http://www.reddit.com/r/howto/comments/1nmt0d/the_best_ways_to_generate_cash_on_the_internet_by/">paulina gretzky</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-10137823095004576882013-11-07T12:36:00.001-08:002013-11-07T12:36:38.038-08:00The Dinner Party<figure class="image inline left" readability="2"><img title="131107_SBR_LukeBarrProvenceILLO" alt="Luke Barr: Provence 1970" src="http://www.slate.com/content/dam/slate/articles/arts/books/2013/11/131101_SBR_illos/131107_SBR_LukeBarrProvenceILLO.jpg.CROP.original-original.jpg"/><p class="credit">Illustration bt Greg Ruth</p><br /></figure><br /><br /> <br /> <br /> <br /><br /><p><span class="drop-capped">W</span>hen I make my grandmother’s breakfast casserole, I’m instantly transported to her bright, warm kitchen on Christmas morning, where it is her annual custom to make the sausage and egg dish along with cool ambrosia salad for breakfast. But at the same time, I’m also back in my little college kitchenette, mixing up the casserole as a birthday surprise for a boy who, as it would soon become apparent, did not like me as much as I liked him. Years later, a bittersweet note discernible only to me is unavoidably melted in with the Cheddar cheese and Worcestershire sauce.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><section class="about-the-author fancy inline with-head" readability="2.35042735043"><br /> <p>J. Bryan Lowder is the assistant editor of Outward, <b><i>Slate</i></b>’s LGBTQ section, and the editorial assistant for culture.</p><br /><br /> <br /> </section><!-- /.about-the-author --><br /><br /> <br /> <br /> <br /><br /><p>The past’s tendency to seep into the meals of our present is a phenomenon well known to Luke Barr, an editor at <em>Travel + Leisure</em> and author of the gorgeous new book, <strong><em>Provence, 1970</em></strong><em>.</em> Barr’s work is a novelistic account of the real winter of 1970-1971 that found American food luminaries Julia and Paul Child, influential cookbook authors Richard Olney and James Beard, Knopf editor Judith Jones, and beloved food writer M.F.K. Fisher—Barr’s great-aunt—gathered together, somewhat by serendipity, in the fragrant hills of Provence. There, over a series of dinner parties (Barr naturally includes the menus), side trips, and sightseeing, the group discussed recipes, wine, their careers, and the state of food culture in France and the United States.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><p>Barr is an excellent writer about the pleasures of cooking and food; there’s enough sizzle in his accounts of these dinners to allow an appreciation of <em>Provence </em>purely on the level of sensuality. It is not easy for me to admit Barr’s descriptions of cooking and eating have in some cases supplanted Julia Child’s own <em>My Life in France</em><em> </em>in my fantasy repertoire. Late in the book, Simone Beck (Child’s cookbook partner and landlord) offers a New Year’s preparation of <em>pot</em><em>ée normande</em>, a rich, multihour stew,<em> </em>which I will inevitably attempt over the holiday season:</p><br /><br /><br /><br /><br /> <br /> <br /> <br /> <br /> <br /><br /><blockquote>When the <em>potée normande </em>was done, Beck made a sauce with some of the cooking broth and heavy cream. This was then served over the thick slices of beef, pork, sausage, and chicken, along with the carrots and leeks. Large bowls were passed around, steam rising from the fragrant meat and soup.</blockquote><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /> <br /> <br /> <br /><br /><p>If that sounds good, know that Barr is even better with the pleasures present beyond the plate. His subtle appreciation for the many intrigues of a dinner party—how, for example, a host’s menu can serve as a shady philosophical argument as much as a tasty suite of courses—is delicious in a way that has nothing to do with the mousseline of sea urchins in aspic. Barr’s access to his great-aunt’s detailed diaries and correspondence (in addition to the memoirs and papers of other characters and interviews with Judith Jones, the local driver, and Barr’s grandmother Norah) infuses <em>Provence </em>with a wonderful gossipy quality that’s as entertaining as it is humanizing, especially to mythic figures like Child. These people were clearly—and necessarily, given their taste-making professions—arrogant, judgmental, and snobbish (often, funnily, about “simplicity” in cooking), and yet none of them quite appreciated just how deeply their work would shake and shape American eating habits in the decades to come.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><p>For looming around these meals, in the shadows just beyond the candlelit table, was the open question of “what next?” By 1970, the innate glamour and long-unassailable preeminence of French cuisine was fading due to a variety of societal factors, and each member of the crew—who had all made their names “mastering” it in one way or another—was hungry for something new. Barr’s book, then, is a portrait of a pivot, a sumptuous record of an encounter not unlike those particle interactions depicted in a Feynman diagram in which the participants approach each other, glow furiously for an instant, and then depart the scene utterly changed.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><br /><br /><br /><figure class="image inline left" readability="2"><img title="131107_SBR_LukeBarrProvenceAUTHOR" alt="Luke Barr: Provence 1970" src="http://www.slate.com/content/dam/slate/articles/arts/books/2013/11/131101_SBR_authors/131107_SBR_LukeBarrProvenceAUTHOR.jpg.CROP.original-original.jpg"/><p class="credit">Photo by Benoit Peverelli courtesy Random House</p><br /></figure><br /><br /> <br /> <br /> <br /><br /><p>Barr’s careful presentation of his characters’ trajectories reveal <em>Provence </em>as an important work of cultural history in the guise of a foodie treat. He asks in his prologue: “Who can know where history actually happens, where or when exactly an idea takes root, or blossoms, or wilts away?” This book is an argument that it is as likely to happen in kitchens and wine cellars as in more traditional halls of power. And why not? As Barr points out, 1970 was a “combustible moment.” “So much was shifting in the larger culture—the politics of identity and style, the parameters of taste, of what it meant to be a sophisticated person,” he writes. Tradition and regimented learning were being replaced with experimentation and improvisation, the backlash against mass-production was strengthening, and the growing influence of multiculturalism suggested that the French way might be just one worthy approach among many. With all that flotsam floating in the air, some of it is bound to drift into the food and change it, and thus, us.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><p>Indeed, if <em>Provence </em>has one flaw, it’s Barr’s overzealous insistence on repetitive and unnecessary <em>This moment would change American culture!</em> signposts. In a story so carefully researched and lovingly controlled, we don’t need any extra directions to find our way from Child’s famous kitchen at La Pitchoune or Olney’s hideaway above Solliès-Toucas to the organic farmer’s markets, locavore-friendly CSAs, and light, modern “new American”(yet French-rooted) cooking that we enjoy today. A brief cameo by Alice Waters of Chez Panisse in the final pages is more than enough to demonstrate the connection.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /><p>But then again, I’m someone who already believes that food amounts to more than what fits on a fork. Barr is likely more interested in convincing less-sympathetic readers that good, thoughtful cooking—its reputation marred today by the more obnoxious strains of foodieism—is more than fussiness or extravagance; as the legacy of the tasty days chronicled in <em>Provence, 1970 </em>proves, small bites can have big consequences.</p><br /><br /><br /><br /><br /> <br /> <br /> <br /><br /> <br /> <br /> <br /><br /> <br /> <br /> <br /><br /><br /><br />Source: <a href="http://www.slate.com/articles/arts/books/2013/11/the_dinner_parties_in_provence_where_julia_child_james_beard_and_m_f_k_fisher.html">http://www.slate.com/articles/arts/books/2013/11/the_dinner_parties_in_provence_where_julia_child_james_beard_and_m_f_k_fisher.html</a><br />Tags: <a href="http://alexmayhugh.com/index.php?album=art&image=AMayhugh02.jpg">charlie hunnam</a> <a href="http://in-shop.com/xe2/index.php?document_srl=447">charlie hunnam</a> <a href="http://karpolan.com/services/html-source-code/http/bromide.bbs.mythem.es/url/karpolan.com/news/articles/1003/25/news090.html">Preachers of LA</a> <a href="http://nsdoc.com/xe/?mid=qna&page=7&sort_index=readed_count&order_type=desc&listStyle=gallery&document_srl=455&cpage=">Cnn.com</a> <a href="http://obd2forum.org/memberlist.php?sid=0d7ce919be44c3a511500a647a62a790">Theresa Vail</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-74544629492367306362013-11-07T12:32:00.001-08:002013-11-07T12:32:05.357-08:00Sid Meier's Ace Patrol: Pacific Skies takes flight on iOS<div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><iframe width="620" height="349" src="//www.youtube.com/embed/Yl46qyA0Jog" frameborder="0" allowfullscreen=""></iframe> <p>2K Games and Firaxis announced Thursday the release of Sid Meier's Ace Patrol: Pacific Skies, a strategy game set in World War II.</p> <p>The sequel to the original Ace Patrol game which debuted on iOS earlier this year, Pacific Skies puts you in charge of a squadron of fighters in the Pacific, in historical battles in places like Pearl Harbor, Midway and Guadalcanal. It's turn-based, and with each turn, you tell your pilots to dive, climb, accelerate, juke and perform aerobatic maneuvers to help take down their foes.</p> <p>You'll be able to combat in both American and Japanese fighter planes through more than 180 missions, upgrading your pilots' abilities and aircraft.</p> <p>In a departure from the first game, Pacific Skies is premium-priced - the original Ace Patrol was free to download, with unlockable content available as In-App Purchases.</p> <ul><li>$4.99 - <a href="https://itunes.apple.com/us/app/sid-meiers-ace-patrol-pacific/id660820012?mt=8&at=10l3Vy&ct=d_im">Download now</a></li> </ul></div></div></div><div id="comment-wrapper-nid-21435"></div><img width='1' height='1' src='http://tipb.com.feedsportal.com/c/33998/f/616881/s/336a4cf3/sc/15/mf.gif' border='0'/><br clear='all'/><div class='mf-viral'><table border='0'><tr><td valign='middle'><a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fwww.imore.com%2Fsid-meiers-ace-patrol-pacific-skies-takes-flight-ios&t=Sid+Meier%27s+Ace+Patrol%3A+Pacific+Skies+takes+flight+on+iOS" target="_blank"><img src="http://res3.feedsportal.com/social/twitter.png" border="0" /></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fwww.imore.com%2Fsid-meiers-ace-patrol-pacific-skies-takes-flight-ios&t=Sid+Meier%27s+Ace+Patrol%3A+Pacific+Skies+takes+flight+on+iOS" target="_blank"><img src="http://res3.feedsportal.com/social/facebook.png" border="0" /></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fwww.imore.com%2Fsid-meiers-ace-patrol-pacific-skies-takes-flight-ios&t=Sid+Meier%27s+Ace+Patrol%3A+Pacific+Skies+takes+flight+on+iOS" target="_blank"><img src="http://res3.feedsportal.com/social/linkedin.png" border="0" /></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fwww.imore.com%2Fsid-meiers-ace-patrol-pacific-skies-takes-flight-ios&t=Sid+Meier%27s+Ace+Patrol%3A+Pacific+Skies+takes+flight+on+iOS" target="_blank"><img src="http://res3.feedsportal.com/social/googleplus.png" border="0" /></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fwww.imore.com%2Fsid-meiers-ace-patrol-pacific-skies-takes-flight-ios&t=Sid+Meier%27s+Ace+Patrol%3A+Pacific+Skies+takes+flight+on+iOS" target="_blank"><img src="http://res3.feedsportal.com/social/email.png" border="0" /></a></td><td valign='middle'></td></tr></table></div><br/><br/><a href="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/1/rc.htm"><img src="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/1/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/2/rc.htm"><img src="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/2/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/3/rc.htm"><img src="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/sc/15/rc/3/rc.img" border="0"/></a><br/><br/><a href="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/a2.htm"><img src="http://da.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/a2.img" border="0"/></a><img width="1" height="1" src="http://pi.feedsportal.com/r/180263708733/u/49/f/616881/c/33998/s/336a4cf3/a2t.img" border="0"/><img src="http://feeds.feedburner.com/~r/TheIphoneBlog/~4/Wt7NivHUyhc" height="1" width="1"/>Source: <a href="http://feedproxy.google.com/~r/TheIphoneBlog/~3/Wt7NivHUyhc/story01.htm">http://feedproxy.google.com/~r/TheIphoneBlog/~3/Wt7NivHUyhc/story01.htm</a><br />Tags: <a href="http://www.meguiars.co.nz/member/202558">Virginia governor race</a> <a href="https://www.ohloh.net/accounts/base35subway">TLC Movie</a> <a href="http://www.machinesitalia.org/index.php/member/763761/">Rihanna Pour It Up Video</a> <a href="http://creattica.com/creatives/kellywells/278570">Derrick Thomas</a> <a href="http://www.2cellos.com/us/users/thomas66cough">cbs sports</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-1100660608757733082013-11-07T12:26:00.001-08:002013-11-07T12:26:46.273-08:00Jennifer Lawrence Will Wear a Wig to Continue "Mockingjay" Shoot<p>Rocking her new pixie cut, <a style="color: #FF5AAD; text-decoration: none" href="/jennifer-lawrence/story" target=""> Jennifer Lawrence</a> attended a fan Q&A session at Yahoo’s Headquarters on Wednesday (November 6).</p><br /><p>The 23-year-old actress was lively as she chatted about her upcoming flick “The Hunger Games: Catching Fire” in the Sunnyvale, CA.</p><br /><p>As for her new ‘do, a friend close to the star chatted with E! News and shared Jen’s reaction to the locks chop. "She loves it!" the source said. </p><br /><p>As for her current work load, Lawrence is will continue to film “Mockingjay” wearing a long brunette wig.</p><br />Source: <a href="http://celebrity-gossip.net/jennifer-lawrence/jennifer-lawrence-will-wear-wig-continue-mockingjay-shoot-957009">http://celebrity-gossip.net/jennifer-lawrence/jennifer-lawrence-will-wear-wig-continue-mockingjay-shoot-957009</a><br />Related Topics: <a href="http://live4.ru/out.php?link=http://helpingonesself.com/make-apple-smoothie">miranda lambert</a> <a href="http://www.wikihouse.com/pukiwiki/jump.php?http://helpingonesself.com/make-apple-smoothie">darren sproles</a> <a href="http://www.shiogama.co.jp/cgi-local/link.cgi?http://helpingonesself.com/make-apple-smoothie">iOS 7 Release Time</a> <a href="http://dontknow.me/at/?http://helpingonesself.com/make-apple-smoothie">Robin Quivers</a> <a href="http://wifi.pokemon-dp.net/battle/link.cgi/helpingonesself.com/make-apple-smoothie">Will Smith Miley Cyrus</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0tag:blogger.com,1999:blog-8809322053985587559.post-17488408914274059152013-11-07T12:20:00.001-08:002013-11-07T12:20:36.571-08:00Lookout security coming to AT&T Android phones<p class="rtecenter"><img alt="Lookout" class="lightbox2 imagecache-w680h550 aligncenter" src="http://www.androidcentral.com/sites/androidcentral.com/files/imagecache/w680h550/postimages/108579/lookout.jpg" /></p> <h3> Security software to be loaded on all compatible AT&T Android devices</h3> <p>Mobile security firm <a href="http://www.androidcentral.com/tags/lookout" title="Lookout">Lookout</a> has announced that it's partnering with <a href="http://www.androidcentral.com/tags/att" title="ATT">AT&T</a> to bring its Android security suite to all compatible AT&T phones in the future. The app, which is already preinstalled on AT&T's <a href="http://www.androidcentral.com/samsung-galaxy-note-3" title="Galaxy Note 3">Galaxy Note 3</a>, is one of the leading antivirus and theft-protection apps on Android, with features designed to repel both digital and physical security threats.</p> <p>Lookout has made the news with a number of high-profile partnerships over the past few months. It recently <a href="http://www.androidcentral.com/samsung-expected-include-lookout-future-devices-increased-enterprise-security" title="Samsung Lookout deal">inked a deal with Samsung</a> to include its software included as part of the KNOX enterprise security suite. And back in July the company <a href="http://www.androidcentral.com/t-mobile-offers-free-lookout-premium-subscriptions-asurion-php-and-jump-customers" title="T-Mobile Lookout deal">partnered with T-Mobile</a> to bring free Lookout security subscriptions to its Asurion PHP and Jump! customers.</p> <p>With both Samsung and AT&T now onboard, Lookout looks set to significantly grow its user base in the months ahead.</p> <p class="rteright">Source: <a href="https://blog.lookout.com/blog/2013/11/07/lookout-brings-security-to-att/" target="_blank">AT&T</a></p><img width='1' height='1' src='http://androidcentral.com.feedsportal.com/c/33995/f/616884/s/336b4600/sc/15/mf.gif' border='0'/><br clear='all'/><div class='mf-viral'><table border='0'><tr><td valign='middle'><a href="http://share.feedsportal.com/share/twitter/?u=http%3A%2F%2Fwww.androidcentral.com%2Flookout-security-coming-att-android-phones&t=Lookout+security+coming+to+AT%26T+Android+phones" target="_blank"><img src="http://res3.feedsportal.com/social/twitter.png" border="0" /></a> <a href="http://share.feedsportal.com/share/facebook/?u=http%3A%2F%2Fwww.androidcentral.com%2Flookout-security-coming-att-android-phones&t=Lookout+security+coming+to+AT%26T+Android+phones" target="_blank"><img src="http://res3.feedsportal.com/social/facebook.png" border="0" /></a> <a href="http://share.feedsportal.com/share/linkedin/?u=http%3A%2F%2Fwww.androidcentral.com%2Flookout-security-coming-att-android-phones&t=Lookout+security+coming+to+AT%26T+Android+phones" target="_blank"><img src="http://res3.feedsportal.com/social/linkedin.png" border="0" /></a> <a href="http://share.feedsportal.com/share/gplus/?u=http%3A%2F%2Fwww.androidcentral.com%2Flookout-security-coming-att-android-phones&t=Lookout+security+coming+to+AT%26T+Android+phones" target="_blank"><img src="http://res3.feedsportal.com/social/googleplus.png" border="0" /></a> <a href="http://share.feedsportal.com/share/email/?u=http%3A%2F%2Fwww.androidcentral.com%2Flookout-security-coming-att-android-phones&t=Lookout+security+coming+to+AT%26T+Android+phones" target="_blank"><img src="http://res3.feedsportal.com/social/email.png" border="0" /></a></td></tr></table></div><br/><br/><a href="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/1/rc.htm"><img src="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/1/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/2/rc.htm"><img src="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/2/rc.img" border="0"/></a><br/><a href="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/3/rc.htm"><img src="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/sc/15/rc/3/rc.img" border="0"/></a><br/><br/><a href="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/a2.htm"><img src="http://da.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/a2.img" border="0"/></a><img width="1" height="1" src="http://pi.feedsportal.com/r/180263341376/u/49/f/616884/c/33995/s/336b4600/a2t.img" border="0"/><img src="http://feeds.feedburner.com/~r/androidcentral/~4/1RXxoMrF0Xk" height="1" width="1"/>Source: <a href="http://feedproxy.google.com/~r/androidcentral/~3/1RXxoMrF0Xk/story01.htm">http://feedproxy.google.com/~r/androidcentral/~3/1RXxoMrF0Xk/story01.htm</a><br />Tags: <a href="http://thearticleplace.net/Article/Is-Teeth-Whitening-Needed-rior-to-the-Placement-of-Crowns-/151414">Giraffe Riddle Answer</a> <a href="http://thearticleplace.net/Article/The-Importance-Of-Black-Line-With-Dental-Crowns/151395">world series game 4</a> <a href="http://thearticleplace.net/Article/Dental-Veneers--Best-Gap-Fillers/151369">dallas cowboys</a> <a href="http://thearticleplace.net/Article/What-Kind-Of-Dental-Work-Do-You-Want-/151354">Government Shutdown Over</a> <a href="http://thearticleplace.net/Article/Gentle-Dental-Tooth-Brushes-and-How-it-Helps/151335">Nothing Was The Same</a> williamrussshttp://www.blogger.com/profile/17985985210233066971noreply@blogger.com0